Bioelectrical impedance analysis-derived phase angle predicts sarcopenia in older adults with type 2 diabetes mellitus

IF 1.8 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Endocrinologia Diabetes Y Nutricion Pub Date : 2026-04-01 Epub Date: 2026-04-21 DOI:10.1016/j.endien.2026.501717

Tingying Xiao , Shiyue Zou , Chunming Yuan , Lijuan Gou , Ying Dai , Fang Chen , Jing Lai , Lixi Yang

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Abstract

Background and objectives

Sarcopenia is prevalent among older patients with type 2 diabetes mellitus (T2DM). The phase angle (PhA), derived from bioelectrical impedance analysis (BIA), is a potential marker for sarcopenia. This study aimed to explore the relationship between PhA and sarcopenia in older patients with T2DM and determine the PhA threshold for predicting sarcopenia.

Methods

We conducted a cross-sectional study with 263 older patients with T2DM hospitalized at a Chinese tertiary referral center. Participants were categorized into sarcopenia (T2DM-SP) and non-sarcopenia (T2DM-NSP) groups. Logistic regression analysis was used to evaluate the PhA as an independent predictor of sarcopenia after adjusting for confounding factors. The receiver operating characteristic (ROC) curve was used to analyze the predictive value of PhA in sarcopenia.

Results

PhA was significantly lower in the T2DM-SP group vs the T2DM-NSP group (4.523 ± 0.627° vs 4.995 ± 0.711°; p < 0.001). Moreover, the PhA was significantly related to sarcopenia, even after adjusting for age, sex, body mass index (BMI), and other covariates, PhA remained independently associated with sarcopenia (OR, 0.112; p = 0.001), low HGS (OR, 0.220; p = 0.007), and low ASMI (OR, 0.083; p < 0.001). ROC curve analysis determined the optimal PhA cutoff values for diagnosing sarcopenia as 5.35° for men (AUC, 0.717; p < 0.001) and 4.55° for women (AUC, 0.745; p < 0.001).

Conclusions

The study identified a significant relationship between sarcopenia and PhA among older patients with T2DM, which may serve as a valuable marker for predicting sarcopenia in this population. Further prospective studies are required to confirm these findings and clarify the underlying mechanisms.

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生物电阻抗分析得出的相位角预测老年2型糖尿病患者的肌肉减少症

背景与目的老年2型糖尿病（T2DM）患者普遍存在肌肉减少症。由生物电阻抗分析（BIA）得出的相位角（PhA）是肌少症的潜在标志。本研究旨在探讨老年T2DM患者PhA与肌肉减少症的关系，并确定预测肌肉减少症的PhA阈值。方法我们对263例在中国三级转诊中心住院的老年T2DM患者进行了横断面研究。参与者被分为肌肉减少症（T2DM-SP）和非肌肉减少症（T2DM-NSP）组。在调整混杂因素后，采用Logistic回归分析评估PhA作为肌肉减少症的独立预测因子。采用受试者工作特征（ROC）曲线分析PhA对肌少症的预测价值。结果T2DM-SP组spha明显低于T2DM-NSP组（4.523±0.627°vs 4.995±0.711°；p < 0.001）。此外，PhA与肌肉减少症显著相关，即使在调整了年龄、性别、体重指数（BMI）和其他协变量后，PhA仍然与肌肉减少症（OR, 0.112; p = 0.001）、低HGS （OR, 0.220; p = 0.007）和低ASMI （OR, 0.083; p < 0.001）独立相关。ROC曲线分析确定诊断肌肉减少症的最佳PhA截断值为男性5.35°（AUC, 0.717; p < 0.001），女性4.55°（AUC, 0.745; p < 0.001）。结论：本研究确定老年T2DM患者肌少症与PhA之间存在显著关系，这可能作为预测该人群肌少症的有价值指标。需要进一步的前瞻性研究来证实这些发现并阐明潜在的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrinologia Diabetes Y Nutricion Multiple-

CiteScore

2.10

自引率

10.50%

发文量

期刊介绍： Endocrinología, Diabetes y Nutrición is the official journal of the Spanish Society of Endocrinology and Nutrition (Sociedad Española de Endocrinología y Nutrición, SEEN) and the Spanish Society of Diabetes (Sociedad Española de Diabetes, SED), and was founded in 1954. The aim of the journal is to improve knowledge and be a useful tool in practice for clinical and laboratory specialists, trainee physicians, researchers, and nurses interested in endocrinology, diabetes, nutrition and related disciplines. It is an international journal published in Spanish (print and online) and English (online), covering different fields of endocrinology and metabolism, including diabetes, obesity, and nutrition disorders, as well as the most relevant research produced mainly in Spanish language territories. The quality of the contents is ensured by a prestigious national and international board, and by a selected panel of specialists involved in a rigorous peer review. The result is that only manuscripts containing high quality research and with utmost interest for clinicians and professionals related in the field are published. The Journal publishes Original clinical and research articles, Reviews, Special articles, Clinical Guidelines, Position Statements from both societies and Letters to the editor. Endocrinología, Diabetes y Nutrición can be found at Science Citation Index Expanded, Medline/PubMed and SCOPUS.