Multi-parametric Quantitative MRI to Evaluate the Value of Pelvic Floor Muscle Dysfunction in POP Patients.

IF 2 3区医学 Q3 OBSTETRICS & GYNECOLOGY

International Urogynecology Journal Pub Date : 2026-09-01 Epub Date: 2026-04-17 DOI:10.1007/s00192-026-06652-1

XiaoYing Wang, Wei Guo, Meng Wang, BaoGen Zhao, HongLiang Hu, Lu Zhang, Yong Wang, Li Zhang

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引用次数: 0

Abstract

Purpose: To explore the application value of multiparameter quantitative MRI in evaluating pelvic floor muscle function in POP patients.

Methods: Sixty-nine POP patients and 32 healthy controls (HC) were prospectively enrolled and categorized into POP _I-II (n = 32) and POP _III-IV (n = 37) groups based on POP-Q. All participants underwent conventional pelvic floor MRI, Q-Dixon, and T1-mapping. The PDFF and native T1 values of pelvic floor muscles were measured. Between-group differences in PDFF and T1 values were compared.

Results: No significant differences were found in the PDFF and native T1 values of the bilateral OIM, OEM, PEC, and COC muscles (P > 0.05). The PDFF of the levator ani muscle (LAM) was significantly higher in the POP _III-IV group than in the POP _I-II and HC groups (P < 0.001). The PDFF of the coccygeus muscle (COC) was higher in both POP groups than in HCs (P < 0.001). Native T1 values of LAM and COC were lower in both POP groups compared to HCs (P < 0.001). Combined PDFF and T1 values of LAM and COC showed good diagnostic performance for POP severity (AUCs 0.826 and 0.841). Interobserver agreement was excellent (ICC 0.807-0.920).

Conclusion: PDFF and native T1 values are valuable biomarkers for assessing pelvic floor muscle dysfunction and stratifying disease severity in patients with POP.

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多参数定量MRI评价POP患者盆底肌功能障碍的价值。

目的：探讨多参数定量MRI在评价POP患者盆底肌功能中的应用价值。方法：前瞻性纳入69例POP患者和32例健康对照（HC），根据POP- q分为POP I-II组（n = 32）和POP III-IV组（n = 37）。所有参与者都进行了常规盆底MRI、Q-Dixon和t1定位。测量盆底肌肉的PDFF和原生T1值。比较PDFF和T1值的组间差异。结果：双侧OIM、OEM、PEC和COC肌肉的PDFF和原生T1值无显著差异（P < 0.05）。POP III-IV组提肛肌（LAM）的PDFF明显高于POP I-II和HC组（P < 0.001）。两组患者尾骨肌（COC）的PDFF均高于hcc组（P < 0.001）。与hc组相比，POP组LAM和COC的T1值均较低（P < 0.001）。LAM和COC的PDFF和T1值对POP的严重程度有较好的诊断价值（auc分别为0.826和0.841）。观察者间一致性极好（ICC 0.807-0.920）。结论：PDFF和原生T1值是评估POP患者盆底肌肉功能障碍和疾病严重程度分层的有价值的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Urogynecology Journal 医学-妇产科学

CiteScore

3.80

自引率

22.20%

发文量

406

审稿时长

3-6 weeks

期刊介绍： The International Urogynecology Journal is the official journal of the International Urogynecological Association (IUGA).The International Urogynecology Journal has evolved in response to a perceived need amongst the clinicians, scientists, and researchers active in the field of urogynecology and pelvic floor disorders. Gynecologists, urologists, physiotherapists, nurses and basic scientists require regular means of communication within this field of pelvic floor dysfunction to express new ideas and research, and to review clinical practice in the diagnosis and treatment of women with disorders of the pelvic floor. This Journal has adopted the peer review process for all original contributions and will maintain high standards with regard to the research published therein. The clinical approach to urogynecology and pelvic floor disorders will be emphasized with each issue containing clinically relevant material that will be immediately applicable for clinical medicine. This publication covers all aspects of the field in an interdisciplinary fashion