Systemic immune-inflammatory index predicts all-cause and cardiovascular mortality in metabolic syndrome: A prospective cohort study using NHANES data

IF 2.4 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Clinics Pub Date : 2026-01-01 Epub Date: 2026-04-16 DOI:10.1016/j.clinsp.2026.100919

Yao Sun , Shuguang Yang , Zengli Xiao , Youzhong An , Huiying Zhao

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引用次数: 0

Abstract

Background

This study aims to evaluate the association between SII and the prevalence of MetS in the female population of the United States, utilizing data from the National Health and Nutrition Examination Survey (NHANES) 2013–2018.

Methods

The study analyzed data from 6140 participants. The association between SII and MetS was investigated using both univariate and multivariable analyses. Additionally, the relationship between SII and all-cause as well as cardiovascular mortality was assessed through Cox proportional hazards regression models.

Results

MetS was prevalent in 37.52% of the study population. Participants diagnosed with MetS showed higher SII scores compared to those without MetS. There was a nonlinear “J”-shaped dose-response relationship between increased SII levels and increased all-cause mortality in the MetS population. The same trend of relationship between SII levels and cardiovascular mortality was observed in people aged 60-years and older in the MetS population.

Conclusion

The results of this study suggest that there is a significant association between elevated SII and the presence of MetS, and that systemic inflammation indicated by SII may contribute to the development and progression of MetS and its associated complications. Further studies are warranted to elucidate the underlying mechanisms between SII and MetS and to evaluate the clinical utility of SII in risk stratification and management strategies.

查看原文本刊更多论文

全身免疫炎症指数预测代谢综合征的全因死亡率和心血管死亡率：一项使用NHANES数据的前瞻性队列研究

本研究旨在利用2013-2018年国家健康与营养检查调查（NHANES）的数据，评估美国女性人群中SII与MetS患病率之间的关系。方法本研究分析了6140名参与者的数据。使用单变量和多变量分析来研究SII和MetS之间的关系。此外，通过Cox比例风险回归模型评估SII与全因死亡率以及心血管死亡率之间的关系。结果37.52%的研究人群患有met。与没有MetS的参与者相比，被诊断患有MetS的参与者表现出更高的SII得分。在met人群中，SII水平升高与全因死亡率升高之间存在非线性的“J”型剂量-反应关系。在60岁及以上的MetS人群中，SII水平与心血管死亡率之间的关系趋势相同。结论本研究结果提示SII升高与MetS存在显著相关性，SII指示的全身性炎症可能促进MetS及其相关并发症的发生和进展。需要进一步的研究来阐明SII和MetS之间的潜在机制，并评估SII在风险分层和管理策略中的临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinics 医学-医学：内科

CiteScore

4.10

自引率

3.70%

发文量

129

审稿时长

52 days

期刊介绍： CLINICS is an electronic journal that publishes peer-reviewed articles in continuous flow, of interest to clinicians and researchers in the medical sciences. CLINICS complies with the policies of funding agencies which request or require deposition of the published articles that they fund into publicly available databases. CLINICS supports the position of the International Committee of Medical Journal Editors (ICMJE) on trial registration.