Programming extracellular protein fate with peptide chimeras

Abstract

Although targeted protein degradation has revolutionized intracellular drug discovery, strategies against extracellular disease-causing proteins remain limited. In Cell, Teng et al. introduce synthetic peptide programmed lysosome targeting chimeras (SPYTACs) to couple extracellular target recognition with receptor-mediated uptake and degradation, reframing extracellular protein degradation as a problem of molecular design.