Association of CDK15 and L1CAM Expression in Cervical Cancer Tissues with Clinicopathological Characteristics and Recurrence/Metastasis After Radical Hysterectomy.
Jingjing Li, Yuanyuan Su, Limin Chen, Yan An, Lin Shen
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引用次数: 0
Abstract
Objective: To investigate the association of CDK15(cyclin-dependent kinase 15) and L1CAM L1 (cell adhesion molecule) expression with clinicopathological characteristics and recurrence and/or metastasis after radical hysterectomy of cervical cancer.
Methodology: Retrospective analysis was performed on the clinical data of 80 patients with pathologically confirmed cervical cancer who underwent radical hysterectomy at Affiliated Hospital of Hebei University between January 2023 to January 2025. Differences in CDK15 and L1CAM L1 expression in cervical cancer tissues were compared across subgroups stratified by different clinicopathological characteristics, including age and International Federation of Gynecology and Obstetrics(FIGO) stage. Recurrence and metastasis in cervical cancer patients were documented within 12 months post-radical hysterectomy. The Kaplan-Meier method was employed to analyze the association of CDK15/L1CAM expression with recurrence-free survival(RFS).
Results: The positive expression rates of CDK15 and L1CAM in cervical cancer tissues were 51.25% and 47.50%, respectively-both significantly higher than the corresponding rates of 22.50% and 18.75% in adjacent non-cancerous tissues(P<0.05). In cervical cancer tissues, the expression of CDK15 exhibited statistically significant differences across subgroups stratified by FIGO stage, histological differentiation, lymph node metastasis, and lymphovascular invasion(P<0.05); whereas the expression of L1CAM demonstrated statistically significant differences across subgroups stratified by FIGO stage, maximum tumor diameter, and lymph node metastasis(P<0.05). Kaplan-Meier analysis revealed that the 12 months RFS rate after radical hysterectomy was approximately 68.29% in cervical cancer patients with positive CDK15 expression, which was lower than the 89.74% in patients with negative CDK15 expression(Log-rank P=0.019).
Conclusion: CDK15 and L1CAM are highly expressed in cervical cancer tissues. Consequently, CDK15 and L1CAM hold promise as novel prognostic biomarkers and potential therapeutic targets for cervical cancer.
期刊介绍：
It is a peer reviewed medical journal published regularly since 1984. It was previously known as quarterly "SPECIALIST" till December 31st 1999. It publishes original research articles, review articles, current practices, short communications & case reports. It attracts manuscripts not only from within Pakistan but also from over fifty countries from abroad.
Copies of PJMS are sent to all the import medical libraries all over Pakistan and overseas particularly in South East Asia and Asia Pacific besides WHO EMRO Region countries. Eminent members of the medical profession at home and abroad regularly contribute their write-ups, manuscripts in our publications. We pursue an independent editorial policy, which allows an opportunity to the healthcare professionals to express their views without any fear or favour. That is why many opinion makers among the medical and pharmaceutical profession use this publication to communicate their viewpoint.
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