Prospective Pilot Study of ¹¹C-acetate and ¹⁸F-FDG with PET/CT and PET/MRI for Lesion Detection in Multiple Myeloma.

IF 2.5 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Molecular Imaging and Biology Pub Date : 2026-04-16 DOI:10.1007/s11307-026-02099-4

Kristina Yancey, Will Han, Ming Yang, Ba D Nguyen, Nan Zhang, Kristin Graf, Kevin G Shim, Erin E Wiedmeier-Nutor, Udit Yadav, Keith Stewart, Saurabh Chhabra, Leif Bergsagel, Mary Ellen Koran, Felipe Martinez, Steve Huang, Michael Roarke, Rafael Fonseca, Clifford H Shin

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引用次数: 0

Abstract

Purpose: To compare the diagnostic performance of ¹¹C-acetate and ¹⁸F-FDG across hybrid PET/CT and PET/MRI platforms in patients with multiple myeloma (MM).

Methods: In this prospective pilot study, seven patients with MM underwent repeated-measures imaging with ¹⁸F-FDG PET/CT, ¹⁸F-FDG PET/MRI, ¹¹C-acetate PET/CT, and ¹¹C-acetate PET/MRI. In addition to lesion quantification, the lesions were visually scored for conspicuity. No functional sequences or contrast-enhancement was used in the MRI protocol.

Results: ¹¹C-acetate detected a greater number of lesions and demonstrated higher visual conspicuity than ¹⁸F-FDG across both PET/CT and PET/MRI platforms.

Conclusion: ¹¹C-acetate PET imaging may offer improved lesion detection compared to ¹⁸F-FDG in MM. Although the advantage of PET/MRI was not observed over PET/CT in this context, further studies incorporating additional MRI sequences and larger cohorts are warranted.

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11c -醋酸酯和18F-FDG在多发性骨髓瘤病变检测中的PET/CT和PET/MRI前瞻性试点研究。

目的：比较11C-acetate和18F-FDG在PET/CT和PET/MRI混合平台上对多发性骨髓瘤（MM）患者的诊断效果。方法：在这项前瞻性先导研究中，7名MM患者接受了18F-FDG PET/CT、18F-FDG PET/MRI、11C-acetate PET/CT和11C-acetate PET/MRI的重复测量成像。除了对病变进行量化外，还对病变的显著性进行了视觉评分。在MRI方案中没有使用功能序列或对比增强。结果：在PET/CT和PET/MRI平台上，11C-acetate比18F-FDG检测到更多的病变，并表现出更高的视觉显著性。结论：与18F-FDG相比，11c -乙酸酯PET成像在MM中可能提供更好的病变检测。尽管在这种情况下PET/MRI没有优于PET/CT的优势，但进一步的研究纳入了额外的MRI序列和更大的队列是有必要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Imaging and Biology 医学-核医学

CiteScore

6.90

自引率

3.20%

发文量

审稿时长

3 months

期刊介绍： Molecular Imaging and Biology (MIB) invites original contributions (research articles, review articles, commentaries, etc.) on the utilization of molecular imaging (i.e., nuclear imaging, optical imaging, autoradiography and pathology, MRI, MPI, ultrasound imaging, radiomics/genomics etc.) to investigate questions related to biology and health. The objective of MIB is to provide a forum to the discovery of molecular mechanisms of disease through the use of imaging techniques. We aim to investigate the biological nature of disease in patients and establish new molecular imaging diagnostic and therapy procedures. Some areas that are covered are: Preclinical and clinical imaging of macromolecular targets (e.g., genes, receptors, enzymes) involved in significant biological processes. The design, characterization, and study of new molecular imaging probes and contrast agents for the functional interrogation of macromolecular targets. Development and evaluation of imaging systems including instrumentation, image reconstruction algorithms, image analysis, and display. Development of molecular assay approaches leading to quantification of the biological information obtained in molecular imaging. Study of in vivo animal models of disease for the development of new molecular diagnostics and therapeutics. Extension of in vitro and in vivo discoveries using disease models, into well designed clinical research investigations. Clinical molecular imaging involving clinical investigations, clinical trials and medical management or cost-effectiveness studies.