Hypertension-induced retinal microvascular remodeling in women.

IF 2.3 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Journal of Vascular Research Pub Date : 2026-04-16 DOI:10.1159/000552087

Rohit S Nampoothiry, Nadra Salman, Ricardo Bernardino de Paula, Laena Pernomian, Paul Townsend, Carolyn M Willmore, Nicholas Riccardi, Sarah E Newman-Norlund, Julius Fridriksson, Leonardo Bonilha, Camilla F Wenceslau, Cameron G McCarthy

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引用次数: 0

Abstract

Background: Hypertension is a major risk factor for cardiovascular disease, yet its effects on the retinal microvasculature in women, independent of pregnancy and diabetes, remain poorly understood.

Methods: We integrated retinal imaging in female participants with structural assessments in hypertensive female mice to evaluate retinal microvascular remodeling.

Results: In women, higher systolic blood pressure was associated with reduced retinal arteriolar area and retinal thinning, independent of BMI or glycemic status. Women over age 50 exhibited greater retinal microvascular loss, suggesting age-related susceptibility. After adjusting for age, retinal arteriolar area remained significantly associated with hypertension, whereas venular area and retinal thickness were primarily associated with age. No significant age x hypertension interactions were observed for any outcome. In parallel, hypertensive BPH/2J mice displayed retinal microvascular rarefaction and reduced pericyte coverage compared with normotensive BPN/3J controls.

Conclusions: Across species, hypertension induced rarefaction, arteriolar loss, and pericyte depletion, indicating impaired microvascular integrity. These findings support the utility of retinal imaging as a noninvasive biomarker of hypertensive microvascular disease in women.

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高血压诱导的女性视网膜微血管重构。

背景：高血压是心血管疾病的主要危险因素，但其对女性视网膜微血管的影响（与妊娠和糖尿病无关）仍知之甚少。方法：我们将女性受试者的视网膜成像与高血压雌性小鼠的结构评估相结合，以评估视网膜微血管重构。结果：在女性中，较高的收缩压与视网膜小动脉面积减少和视网膜变薄有关，与BMI或血糖状态无关。50岁以上的女性表现出更大的视网膜微血管丧失，表明年龄相关的易感性。在调整年龄后，视网膜小动脉面积仍然与高血压显著相关，而静脉面积和视网膜厚度主要与年龄相关。没有观察到明显的年龄与高血压的相互作用。与此同时，与正常BPN/3J对照组相比，高血压BPH/2J小鼠表现出视网膜微血管稀疏和周细胞覆盖减少。结论：在所有物种中，高血压引起血管稀疏、小动脉丢失和周细胞消耗，表明微血管完整性受损。这些发现支持视网膜成像作为女性高血压微血管疾病的无创生物标志物的效用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Vascular Research 医学-生理学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The ''Journal of Vascular Research'' publishes original articles and reviews of scientific excellence in vascular and microvascular biology, physiology and pathophysiology. The scope of the journal covers a broad spectrum of vascular and lymphatic research, including vascular structure, vascular function, haemodynamics, mechanics, cell signalling, intercellular communication, growth and differentiation. JVR''s ''Vascular Update'' series regularly presents state-of-the-art reviews on hot topics in vascular biology. Manuscript processing times are, consistent with stringent review, kept as short as possible due to electronic submission. All articles are published online first, ensuring rapid publication. The ''Journal of Vascular Research'' is the official journal of the European Society for Microcirculation. A biennial prize is awarded to the authors of the best paper published in the journal over the previous two years, thus encouraging young scientists working in the exciting field of vascular biology to publish their findings.