{"title":"A Master Conductor: How the SIFamide Neuropeptide System Orchestrates Behavioral State in Drosophila.","authors":"Tianmu Zhang, Woo Jae Kim","doi":"10.1002/bies.70137","DOIUrl":null,"url":null,"abstract":"<p><p>How does the brain prioritize competing drives like hunger, sleep, and mating? In Drosophila, the neuropeptide SIFamide (SIFa) has emerged as a central coordinator of these behavioral states. This commentary synthesizes recent findings, highlighting the study by Velazquez et al., which reveals that SIFa receptor signaling regulates sleep and feeding in a time-of-day-specific manner to maintain energy homeostasis. We further discuss how SIFa modulates reproductive behavior through synaptic plasticity in male-specific GABAergic neurons. Anatomically, SIFa neurons act as an integration hub, receiving convergent circadian and metabolic inputs to bias downstream circuits. We propose that the SIFa system serves as a master conductor, orchestrating adaptive behavioral decisions based on internal physiological needs.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"48 4","pages":"e70137"},"PeriodicalIF":3.3000,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BioEssays","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1002/bies.70137","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
How does the brain prioritize competing drives like hunger, sleep, and mating? In Drosophila, the neuropeptide SIFamide (SIFa) has emerged as a central coordinator of these behavioral states. This commentary synthesizes recent findings, highlighting the study by Velazquez et al., which reveals that SIFa receptor signaling regulates sleep and feeding in a time-of-day-specific manner to maintain energy homeostasis. We further discuss how SIFa modulates reproductive behavior through synaptic plasticity in male-specific GABAergic neurons. Anatomically, SIFa neurons act as an integration hub, receiving convergent circadian and metabolic inputs to bias downstream circuits. We propose that the SIFa system serves as a master conductor, orchestrating adaptive behavioral decisions based on internal physiological needs.
期刊介绍：
molecular – cellular – biomedical – physiology – translational research – systems - hypotheses encouraged
BioEssays is a peer-reviewed, review-and-discussion journal. Our aims are to publish novel insights, forward-looking reviews and commentaries in contemporary biology with a molecular, genetic, cellular, or physiological dimension, and serve as a discussion forum for new ideas in these areas. An additional goal is to encourage transdisciplinarity and integrative biology in the context of organismal studies, systems approaches, through to ecosystems, where appropriate.
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