Prevalence and associations of hyper-reflective bodies in the posterior vitreous: The Beijing eye study

IF 3 3区医学 Q1 OPHTHALMOLOGY

Acta Ophthalmologica Pub Date : 2026-10-09 Epub Date: 2026-04-16 DOI:10.1111/aos.70139

Jost B. Jonas, Songhomitra Panda-Jonas, Rahul A. Jonas, Ya Xing Wang

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引用次数: 0

Abstract

Purpose

To assess prevalence and associations of intra-vitreal hyper-reflective bodies (vHRBs) in the posterior vitreous in a general population.

Methods

Participants of the population-based Beijing Eye Study underwent systemic and ophthalmological examinations. We included into this study a randomly selected group of normal eyes without retinal diseases and a randomly selected group of eyes with age-related macular degeneration (AMD), polypoidal choroidal vasculopathy (PVC) or central serous choroidopathy (CSC). Using serial optical coherence tomography scans of the posterior fundus region, we searched for vHRBs in the posterior vitreous compartment.

Results

The study consisted of 1347 eyes (age: 64.3 ± 9.8 years, range: 50–91 years; axial length: 23.04 ± 1.00 mm, range: 19.39–28.93 mm). vHRB were detected in 314/1347 eyes (23.3%; 95% confidence interval [CI]: 21.1, 25.6), that is, in 137 out of 447 normal eyes (28.9%; 95% CI: 24.8, 33.0), 110/458 eyes with early AMD (24.0%; 95% CI: 20.1, 27.9), 45/278 eyes with intermediate AMD (16.2%; 95% CI: 11.8, 20.5), 3/35 eyes with PCV (8.6%; 95% CI: 0.00, 18.3), and in 19/94 eyes with CSC (20.2%; 95% CI: 11.9, 28.5). In multivariable analysis, higher vHRB prevalence was associated with younger age (OR: 0.93; 95% CI: 0.91, 0.95; p < 0.001), shorter axial length (OR: 0.69; 95% CI:0.56, 0.84; p < 0.001), and lower stage of posterior vitreous detachment (OR: 0.53; 95% CI: 0.44, 0.64; p < 0.001). It was independent of AMD stage (p = 0.87), and prevalence of PCV (p = 0.67) and CSC (p = 0.40). Higher amount of vHRBs (multivariable linear regression analysis) correlated with younger age (beta: −0.21; B: −0.02; 95% CI: −0.03, −0.02; p < 0.001), shorter axial length (beta: −0.07; B: −0.09; 95% CI: −0.16, −0.02; p = 0.009) and lower stage of posterior vitreous detachment (beta: −0.15; B: −0.13; 95% CI: −0.19, −0.08; p < 0.001).

Conclusions

vHRBs were detected in one out of four normal eyes of individuals aged 50+ years, in dependence on younger age, shorter axial length and lower degree of posterior vitreous detachment. They were independent of a concurrence of AMD, PCV and CSC.

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后玻璃体高反射体的患病率及其相关性：北京眼的研究。

目的：评估普通人群后玻璃体玻璃体内高反射体（vHRBs）的患病率及其相关性。方法：以人群为基础的北京眼科研究的参与者接受了系统和眼科检查。我们在这项研究中随机选择了一组没有视网膜疾病的正常眼睛和一组随机选择的患有年龄相关性黄斑变性（AMD）、息肉样脉络膜血管病变（PVC）或中枢性浆液性脉络膜病变（CSC）的眼睛。通过对后眼底区域进行连续光学相干断层扫描，我们在后玻璃体隔室中寻找vhrb。结果：共纳入1347只眼（年龄：64.3±9.8岁，范围：50 ~ 91岁；眼轴长度：23.04±1.00 mm，范围：19.39 ~ 28.93 mm）。在314/1347只眼（23.3%，95%可信区间[CI]: 21.1, 25.6）中检测到vHRB，即447只正常眼中的137只（28.9%,95% CI: 24.8, 33.0），早期AMD的110/458只眼（24.0%,95% CI: 20.1, 27.9），中度AMD的45/278只眼（16.2%,95% CI: 11.8, 20.5）， PCV的3/35只眼（8.6%,95% CI: 0.00, 18.3）， CSC的19/94只眼（20.2%,95% CI: 11.9, 28.5）。在多变量分析中，较高的vHRB患病率与较年轻的年龄相关（OR: 0.93; 95% CI: 0.91, 0.95; p）。结论：在50岁以上的个体中，每4只正常眼中就有1只检测到vHRB，与较年轻、较短的眼轴长度和较低程度的玻璃体后脱离有关。它们独立于AMD、PCV和CSC的并发。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Ophthalmologica 医学-眼科学

CiteScore

7.60

自引率

5.90%

发文量

433

审稿时长

6 months

期刊介绍： Acta Ophthalmologica is published on behalf of the Acta Ophthalmologica Scandinavica Foundation and is the official scientific publication of the following societies: The Danish Ophthalmological Society, The Finnish Ophthalmological Society, The Icelandic Ophthalmological Society, The Norwegian Ophthalmological Society and The Swedish Ophthalmological Society, and also the European Association for Vision and Eye Research (EVER). Acta Ophthalmologica publishes clinical and experimental original articles, reviews, editorials, educational photo essays (Diagnosis and Therapy in Ophthalmology), case reports and case series, letters to the editor and doctoral theses.