[PDCD4 as tumor suppressor protein in gastric mucosa in early, advanced precancerous lesions and gastric adenocarcinoma].

Q4 Medicine

Arkhiv patologii Pub Date : 2026-01-01 DOI:10.17116/patol2026880216

A V Kononov, V A Rubtsov, E G Pomorgailo, S I Mozgovoi, A G Shimanskaya, M V Markelova

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引用次数: 0

Abstract

The PDCD4 (programmed cell death protein 4) protein is a key target protein, in particular for the well-studied miR-21. By suppressing its synthesis, miR-21 exerts its influence on key cellular biological processes. Furthermore, miR-21 itself is one of the most relevant predictor markers for assessing the risk of developing gastric cancer.

Objective: Evaluation of PDCD4 expression as a potential marker for gastric cancer prediction and in the differential diagnosis of gastric mucosal dysplasia.

Material and methods: Comparative immunohistochemical analysis of PDCD4 protein was performed in biopsy specimens of the antral gastric mucosa with signs of chronic gastritis and gastric mucosal dysplasia, as well as in surgical specimens from stomachs resected for adenocarcinoma.

Results: In gastric mucosa with signs of chronic gastritis, high immunohistochemical expression of PDCD4 was maintained, regardless of the severity of inflammation, atrophy, and type of metaplasia. PDCD4 protein expression in the dysplasia group was significantly lower compared to gastric mucosal biopsy samples with signs of chronic gastritis (p=0.00001) and did not differ from that in adenocarcinoma tissues (p=0.43). A simple logistic regression model demonstrated a significant negative association between PDCD4 protein expression and dysplasia in the gastric mucosa (OR=0.27, CI=[0.16-0.46]).

Conclusion: Low PDCD4 protein expression in dysplasia in the gastric mucosa and high levels regardless of the presence and severity of atrophy and inflammation may indicate its high potential for use in the differential diagnosis of indefinite for dysplasia and true dysplasia of the gastric mucosa.

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[PDCD4在早期、晚期癌前病变及胃腺癌中作为抑癌蛋白]。

PDCD4（程序性细胞死亡蛋白4）蛋白是一个关键的靶蛋白，特别是对于已经得到充分研究的miR-21。miR-21通过抑制其合成，对关键的细胞生物学过程产生影响。此外，miR-21本身是评估胃癌发生风险最相关的预测指标之一。目的：评价PDCD4表达在胃癌预测及胃黏膜发育不良鉴别诊断中的价值。材料和方法：对慢性胃炎和胃黏膜发育不良征象的胃胃窦黏膜活检标本以及腺癌切除胃手术标本进行PDCD4蛋白比较免疫组化分析。结果：在慢性胃炎体征的胃黏膜中，无论炎症程度、萎缩程度、化生类型如何，PDCD4的免疫组化表达均保持在较高水平。与慢性胃炎症状的胃粘膜活检样本相比，非典型增生组的PDCD4蛋白表达明显降低（p=0.00001），与腺癌组织的PDCD4蛋白表达无差异（p=0.43）。简单logistic回归模型显示PDCD4蛋白表达与胃黏膜发育不良呈显著负相关（OR=0.27， CI=[0.16-0.46]）。结论：PDCD4蛋白在胃黏膜不典型增生中的低表达和无论萎缩和炎症是否存在及严重程度的高表达可能表明其在鉴别胃黏膜不典型增生和真不典型增生方面具有很高的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Arkhiv patologii Medicine-Pathology and Forensic Medicine

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： The journal deals with original investigations on pressing problems of general pathology and pathologic anatomy, newest research methods, major issues of the theory and practice as well as problems of experimental, comparative and geographic pathology. To inform readers latest achievements of Russian and foreign medicine the journal regularly publishes editorial and survey articles, reviews of the most interesting Russian and foreign books on pathologic anatomy, new data on modern methods of investigation (histochemistry, electron microscopy, autoradiography, etc.), about problems of teaching, articles on the history of pathological anatomy development both in Russia and abroad.