Genetic and vaccination studies reveal feather viral load as a potential biomarker for individual and flock-level protection against Marek's disease in chicken.

IF 2.7 2区农林科学 Q1 VETERINARY SCIENCES

Avian Pathology Pub Date : 2026-08-01 Epub Date: 2026-06-22 DOI:10.1080/03079457.2026.2661686

Hector Marina, Richard I Bailey, Jody Mays, Marie Ithurbide, Margo Chase-Topping, Hans Cheng, John R Dunn, Andrea Doeschl-Wilson

引用次数: 0

Abstract

Research highlights: Vaccination against MD can confer significant reduction in virus shedding, causing beneficial direct and flock-level protection.Selection for genetic resistance to MD based on tumour incidence or death did not confer significant downstream flock-level protection in this study.Feather viral load emerged as a promising biomarker for both individual and flock-level protection from MD.Reduction of MDV transmission is likely to be the most promising method for long-term MD control.

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遗传和疫苗研究表明，羽毛病毒载量是鸡个体和群体预防马立克病的潜在生物标志物。

尽管通过生物安全、疫苗接种和遗传选择进行了控制，马立克氏病仍然是对家禽的主要威胁。马立克氏病病毒（MDV），病原体，继续存在并进化为增加的毒力，表明目前的措施是不理想的。虽然接种疫苗——即使是“有漏洞”的疫苗——已被证明通过减少病毒脱落，在畜群水平上减少MD症状和死亡率，但尚不清楚遗传抗性是否提供类似的间接保护。通过在近交系蛋鸡中进行自然传播实验，我们比较了疫苗接种和遗传抗性（定义为肿瘤发生率降低和存活率增加）对病毒接种的脱毛鸟和未接种MD易感接触鸟的病毒脱落和MD结果的影响。具有遗传或疫苗介导抗性的脱毛鸟患病和死亡的可能性较小，但只有接种过疫苗的脱毛鸟羽毛病毒载量（FVL）显著降低。几乎所有接触过的鸟类都被感染了，这表明无论是遗传抗性还是疫苗接种都无法阻止传播。然而，症状性口蹄疫发病率和死亡率的显著降低仅在接触接种疫苗的脱落者中观察到。暴露时间相对于脱落者感染时间也影响接触结果。过程分析和剂量-反应曲线显示，高脱毛率或高群雄脱毛率与接触禽的MD发病率、死亡率和脱毛率密切相关。FVL作为个体和群体水平保护的一个有希望的指标，可以作为未来旨在减少MDV传播和限制毒力进化的育种和疫苗接种策略的有用表型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Avian Pathology 农林科学-兽医学

CiteScore

4.50

自引率

10.70%

发文量

审稿时长

1 months

期刊介绍： Avian Pathology is the official journal of the World Veterinary Poultry Association and, since its first publication in 1972, has been a leading international journal for poultry disease scientists. It publishes material relevant to the entire field of infectious and non-infectious diseases of poultry and other birds. Accepted manuscripts will contribute novel data of interest to an international readership and will add significantly to knowledge and understanding of diseases, old or new. Subject areas include pathology, diagnosis, detection and characterisation of pathogens, infections of possible zoonotic importance, epidemiology, innate and immune responses, vaccines, gene sequences, genetics in relation to disease and physiological and biochemical changes in response to disease. First and subsequent reports of well-recognized diseases within a country are not acceptable unless they also include substantial new information about the disease or pathogen. Manuscripts on wild or pet birds should describe disease or pathogens in a significant number of birds, recognizing/suggesting serious potential impact on that species or that the disease or pathogen is of demonstrable relevance to poultry. Manuscripts on food-borne microorganisms acquired during or after processing, and those that catalogue the occurrence or properties of microorganisms, are unlikely to be considered for publication in the absence of data linking them to avian disease.