EnT [2 + 2] cycloaddition enables the synthesis of cyclic sulfinamides and drug bioisosteres

IF 11.6 Q1 CHEMISTRY, PHYSICAL

Chem Catalysis Pub Date : 2026-04-16 DOI:10.1016/j.checat.2026.101720

Fen-Ya Xiong, Yi Wei, Liang-Qiu Lu

引用次数: 0

Abstract

In a recent issue of Science, Willis and co-workers reported the [2 + 2] photocycloaddition of N-silyl sulfinylamines with alkenes via energy transfer (EnT) catalysis. This method provides efficient access to diverse four-membered cyclic sulfinamides, which serve as versatile intermediates for the modular synthesis of β-sultams and aza-β-sultams.

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EnT[2 + 2]环加成可以合成环亚胺和药物生物异构体

在最近一期的《科学》杂志上，威利斯和他的同事报道了通过能量转移（EnT）催化n -硅基亚胺与烯烃的[2 + 2]光环加成反应。该方法提供了多种四元环亚胺的有效途径，这些四元环亚胺作为模块化合成β-磺胺和aza-β-磺胺的多功能中间体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chem Catalysis

CiteScore

10.50

自引率

6.40%

发文量

期刊介绍： Chem Catalysis is a monthly journal that publishes innovative research on fundamental and applied catalysis, providing a platform for researchers across chemistry, chemical engineering, and related fields. It serves as a premier resource for scientists and engineers in academia and industry, covering heterogeneous, homogeneous, and biocatalysis. Emphasizing transformative methods and technologies, the journal aims to advance understanding, introduce novel catalysts, and connect fundamental insights to real-world applications for societal benefit.