Exclusive enteral nutrition and the risk of nonsurgical readmission in patients with Crohn's disease-related intra-abdominal abscess: A retrospective cohort study

IF 3.3 3区医学 Q2 NUTRITION & DIETETICS

Journal of Parenteral and Enteral Nutrition Pub Date : 2026-07-09 Epub Date: 2026-04-15 DOI:10.1002/jpen.70090

Zhihong Zhang MD, Tanxing Cai MD, Hao Xie MD, Renhan Luo MD, Huashan Liu MD, PhD, Wenxin Li MD, PhD, Ziwei Zeng MD, PhD, Zhenxing Liang MD, PhD, Li Xiong MD, PhD, Xiaosheng He MD, PhD, Liang Huang MD, PhD, Liang Kang MD, PhD, Xiaobin Zheng MD, PhD

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引用次数: 0

Abstract

Background

Intra-abdominal abscess management in Crohn's disease patients represents a significant clinical challenge. This study sought to assess the impact of exclusive enteral nutrition on nonsurgical readmission in patients with Crohn's disease-related intra-abdominal abscess.

Methods

This retrospective cohort study was conducted between January 2016 and June 2022 included Crohn's disease patients hospitalized for intra-abdominal abscess. Patients were categorized based on exclusive enteral nutrition administration during hospital stay or not. The primary outcome was nonsurgical readmission within 1-year post-discharge. Secondary outcomes included surgical intervention and abscess recurrence. Multivariable logistic regression analysis and Cox regression analysis were performed to adjust for potential confounding factors.

Results

A total of 128 patients were enrolled, with 45 allocated to the exclusive enteral nutrition group and 83 to the nonexclusive enteral nutrition group. Compared to the nonexclusive enteral nutrition group, patients treated with exclusive enteral nutrition were less likely to require nonsurgical readmissions (42.2% vs 79.5%, P < 0.001). The multivariate analysis confirmed exclusive enteral nutrition as an independent protective factor against nonsurgical readmissions (hazard ratio: 0.11; 95% confidence interval: 0.04–0.30; P < 0.001). In addition, exclusive enteral nutrition group showed a significantly lower rate of surgical intervention (46.7% vs 75.9%, P = 0.01). Notably, abscess recurrence rates remained comparable between groups.

Conclusion

This study provides novel evidence that exclusive enteral nutrition is associated with reduced risks of nonsurgical readmission and surgical burden without affecting abscess recurrence rates in patients with Crohn's disease-related intra-abdominal abscess.

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克罗恩病相关腹内脓肿患者的独家肠内营养和非手术再入院风险：一项回顾性队列研究

背景：克罗恩病患者腹内脓肿的处理是一个重大的临床挑战。本研究旨在评估纯肠内营养对克罗恩病相关腹内脓肿患者非手术再入院的影响。方法：本回顾性队列研究于2016年1月至2022年6月期间进行，纳入因腹腔内脓肿住院的克罗恩病患者。根据住院期间是否单独肠内营养管理对患者进行分类。主要终点为出院后1年内的非手术再入院。次要结果包括手术干预和脓肿复发。采用多变量logistic回归分析和Cox回归分析对潜在的混杂因素进行校正。结果：共纳入128例患者，其中45例分配到独家肠内营养组，83例分配到非独家肠内营养组。与非排他性肠内营养组相比，排他性肠内营养组患者需要非手术再入院的可能性更低（42.2% vs 79.5%）。结论：本研究提供了新的证据，证明排他性肠内营养与降低非手术再入院风险和手术负担相关，而不影响克罗恩病相关腹内脓肿的复发率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Parenteral and Enteral Nutrition 医学-营养学

CiteScore

7.80

自引率

8.80%

发文量

161

审稿时长

6-12 weeks

期刊介绍： The Journal of Parenteral and Enteral Nutrition (JPEN) is the premier scientific journal of nutrition and metabolic support. It publishes original peer-reviewed studies that define the cutting edge of basic and clinical research in the field. It explores the science of optimizing the care of patients receiving enteral or IV therapies. Also included: reviews, techniques, brief reports, case reports, and abstracts.