Effects of maternal arginine supplementation during lactation on offspring growth and wound healing in an experimental rat model of intrauterine malnutrition.

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Acta cirurgica brasileira Pub Date : 2026-04-10 eCollection Date: 2026-01-01 DOI:10.1590/acb411626

Ayrton Alves Aranha Junior, Jorge Eduardo Fouto Matias, Djanira Aparecida da Luz Veronez, Lucia de Noronha, João Carlos Repka, Rafaella Toledo Aranha, Antônio Carlos Ligocki Campos

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Abstract

Purpose: To evaluate the effects of maternal arginine-enriched diet during lactation, following gestational undernutrition, on offspring growth and wound healing.

Methods: Pregnant Wistar rats were divided into two groups during gestation: control (C; ad libitum diet) and undernourished (Und; 60% of control diet). After delivery, the undernourished mothers were reassigned to two subgroups: ad libitum + Impact® (Arg) and ad libitum + Nutren® (Hh). Evaluated parameters included offspring anthropometric measurements, serum albumin, tensile strength, and collagen morphometry at the surgical wound. Statistical analyses included analysis of variance (ANOVA) and Tukey's, Student's t-test, and Fisher's test.

Results: Maternal immunonutrition during lactation promoted recovery of offspring weight (C = 29.21 ± 2.86 g; Arg = 36.08 ± 5.38 g; p = 0.0009) and body length (C = 9.87 ± 0.32 cm; Arg = 10.91 ± 0.73 cm; p = 0.0008), shifting values from significantly lower at birth to higher than controls by weaning. Offspring healing parameters showed no significant differences compared with controls.

Conclusion: An arginine-enriched diet provided to lactating rats malnourished during gestation significantly improved offspring anthropometric growth and supported wound healing following surgery at weaning.

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哺乳期间母体补充精氨酸对子代生长和子宫内营养不良大鼠伤口愈合的影响。

目的：评价妊娠期营养不良的哺乳期母体补充精氨酸对子代生长和伤口愈合的影响。方法：将妊娠期Wistar大鼠分为两组：对照组（C，自由饮食）和营养不良组（d， 60%对照组饮食）。分娩后，营养不良的母亲被重新分配到两个亚组：自由+影响®（Arg）和自由+营养®（Hh）。评估参数包括后代的人体测量、血清白蛋白、抗拉强度和手术伤口处的胶原形态测量。统计分析包括方差分析（ANOVA）和Tukey检验、学生t检验和Fisher检验。结果：哺乳期母体免疫营养促进子代体重（C = 29.21±2.86 g; Arg = 36.08±5.38 g; p = 0.0009）和体长（C = 9.87±0.32 cm; Arg = 10.91±0.73 cm; p = 0.0008）的恢复，并在断奶后由出生时显著低于对照组转为高于对照组。与对照组相比，子代愈合参数无显著差异。结论：给妊娠期营养不良的哺乳期大鼠提供富含精氨酸的饮食，可以显著改善后代的人体测量生长，并支持断奶后手术后的伤口愈合。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Acta cirurgica brasileira

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