Optimizing Pediatric Drug Therapy: Pediatric Pharmacokinetics and Administration Routes.

Abstract

Optimizing pediatric drug therapy requires a comprehensive understanding of the unique pharmacokinetic characteristics in pediatrics, alongside appropriate drug administration routes. This review explores the impact of age-related pharmacokinetic variations, including enzymatic maturation and organ function, on drug absorption, distribution, metabolism, and excretion. The challenges and advantages of various drug administration routes, evaluating their effect on drug efficacy and safety in pediatric populations are also addressed. A multidisciplinary framework is proposed, integrating pharmacokinetic principles with customized drug administration routes and adherence strategies, such as simplified dosing and digital health interventions. Our findings highlight the necessity of a personalized approach to pediatric drug therapy that combines pharmacokinetic insights with practical administration considerations.