Eric Y Helm, Tighe Christopher, Alejandra Lopez Espinoza, Natalie Santillano, Elia D Tait Wojno
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引用次数: 0
Abstract
Soil-transmitted helminths (STHs) infect over a billion people worldwide. Individual outcomes vary, ranging from subclinical, mild infections to recurrent or severe disease. Emerging evidence reveals that susceptibility to STH infection reflects a multilayered integration of past and present environmental factors. At mucosal surfaces, STHs activate type 2 immune, epithelial, and neuronal circuits, while microbial- and diet-derived signals promote homeostasis. Environmental signals tune the transcriptional programs that control these events, shaping interleukin-13-driven effector functions required for worm expulsion. Concurrently, infection and inflammation history imprint immune and epithelial compartments, leading to durable epigenetic remodeling and altering responsiveness to STHs upon reexposure. Understanding how environmental factors impact host-helminth interactions offers new opportunities to predict susceptibility and design interventions that enhance anti-helminth immunity.
期刊介绍：
Since its inception as Parasitology Today in 1985, Trends in Parasitology has evolved into a highly esteemed review journal of global significance, reflecting the importance of medical and veterinary parasites worldwide. The journal serves as a hub for communication among researchers across all disciplines of parasitology, encompassing endoparasites, ectoparasites, transmission vectors, and susceptible hosts.
Each monthly issue of Trends in Parasitology offers authoritative, cutting-edge, and yet accessible review articles, providing a balanced and comprehensive overview, along with opinion pieces offering personal and novel perspectives. Additionally, the journal publishes a variety of short articles designed to inform and stimulate thoughts in a lively and widely-accessible manner. These include Science & Society (discussing the interface between parasitology and the general public), Spotlight (highlighting recently published research articles), Forum (presenting single-point hypotheses), Parasite/Vector of the Month (featuring a modular display of the selected species), Letter (providing responses to recent articles in Trends in Parasitology), and Trendstalk (conducting interviews). Please note that the journal exclusively publishes literature reviews based on published data, with systematic reviews, meta-analysis, and unpublished primary research falling outside our scope.
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