Extracellular Vesicles in Pancreatic Cancer Function and Potential Clinical Applications.

IF 2.8 4区医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

OncoTargets and therapy Pub Date : 2026-04-08 eCollection Date: 2026-01-01 DOI:10.2147/OTT.S591622

Dai Li, Jian-Jun Fang, Zhi-Long Jiang

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引用次数: 0

Abstract

Pancreatic cancer (PC) is one of the most aggressive gastrointestinal malignancies, characterized by a dismal 5-year survival rate. This poor prognosis is primarily attributed to delayed early detection, rapid disease progression, surgical complexities, and the limited efficacy of conventional oncological therapies. Extracellular vesicles (EVs) are nanoscale, cell-secreted vesicles that transport bioactive cargoes, including nucleic acids, proteins, and lipids. Upon release into the extracellular space, EVs facilitate short and long-distance intercellular communication and molecular transport via multiple pathways. In this review, we elucidate the multifaceted roles of EVs within the highly malignant PC microenvironment, specifically focusing on their mediation of intricate crosstalk between tumor and stromal cells. Furthermore, we summarize potential EV-based biomarkers for PC diagnosis and the recent advances in leveraging EVs as therapeutic platforms across radiotherapy, gene therapy, and immunotherapy. Ultimately, this review aims to provide novel insights into the clinical management of PC to improve patient outcomes and quality of life.

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细胞外囊泡在胰腺癌中的功能及潜在临床应用。

胰腺癌（PC）是最具侵袭性的胃肠道恶性肿瘤之一，其5年生存率低。这种不良预后主要是由于早期发现延迟、疾病进展迅速、手术复杂性和传统肿瘤治疗效果有限。细胞外囊泡（EVs）是纳米级的细胞分泌囊泡，可运输生物活性物质，包括核酸、蛋白质和脂质。释放到细胞外空间后，ev通过多种途径促进细胞间的短距离和远距离通信和分子运输。在这篇综述中，我们阐明了ev在高度恶性PC微环境中的多方面作用，特别关注它们介导肿瘤和间质细胞之间复杂的串扰。此外，我们总结了潜在的基于ev的PC诊断生物标志物，以及利用ev作为放射治疗、基因治疗和免疫治疗平台的最新进展。最终，本综述旨在为PC的临床管理提供新的见解，以改善患者的预后和生活质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

OncoTargets and therapy BIOTECHNOLOGY & APPLIED MICROBIOLOGY-ONCOLOGY

CiteScore

9.70

自引率

0.00%

发文量

221

审稿时长

1 months

期刊介绍： OncoTargets and Therapy is an international, peer-reviewed journal focusing on molecular aspects of cancer research, that is, the molecular diagnosis of and targeted molecular or precision therapy for all types of cancer. The journal is characterized by the rapid reporting of high-quality original research, basic science, reviews and evaluations, expert opinion and commentary that shed novel insight on a cancer or cancer subtype. Specific topics covered by the journal include: -Novel therapeutic targets and innovative agents -Novel therapeutic regimens for improved benefit and/or decreased side effects -Early stage clinical trials Further considerations when submitting to OncoTargets and Therapy: -Studies containing in vivo animal model data will be considered favorably. -Tissue microarray analyses will not be considered except in cases where they are supported by comprehensive biological studies involving multiple cell lines. -Biomarker association studies will be considered only when validated by comprehensive in vitro data and analysis of human tissue samples. -Studies utilizing publicly available data (e.g. GWAS/TCGA/GEO etc.) should add to the body of knowledge about a specific disease or relevant phenotype and must be validated using the authors’ own data through replication in an independent sample set and functional follow-up. -Bioinformatics studies must be validated using the authors’ own data through replication in an independent sample set and functional follow-up. -Single nucleotide polymorphism (SNP) studies will not be considered.