Ilja van Lingen, Stefanie Slot, Marije M G Krul, Linda de Nooij, Sjoerd H de Hoog
{"title":"[Deep vein thrombosis resulting in arterial occlusion].","authors":"Ilja van Lingen, Stefanie Slot, Marije M G Krul, Linda de Nooij, Sjoerd H de Hoog","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>A patent foramen ovale (PFO) is present in approximately 25-30% of adults and is usually asymptomatic. However, under conditions of elevated right heart pressure, a PFO can enable right-to-left shunting, allowing venous thrombi to enter the arterial circulation: a mechanism known as paradoxical embolism. We present a case of a 51-year-old woman who developed dyspnea, abdominal pain and, a painful swollen leg. Imaging revealed a saddle pulmonary embolism, renal and splenic infarctions and occlusion of the right brachial artery. Echocardiography confirmed the presence of a PFO. Other common sites of paradoxical embolism include the brain, mesenteric circulation, and coronary arteries. In patients with venous thrombosis, clinicians should carefully assess for signs of concomitant arterial embolism: examine the abdomen, evaluate peripheral pulses in the limbs and perform a basic neurological examination. This case highlights the importance of thorough clinical evaluation to ensure timely recognition of this potentially serious condition.</p>","PeriodicalId":18903,"journal":{"name":"Nederlands tijdschrift voor geneeskunde","volume":"170 ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nederlands tijdschrift voor geneeskunde","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
A patent foramen ovale (PFO) is present in approximately 25-30% of adults and is usually asymptomatic. However, under conditions of elevated right heart pressure, a PFO can enable right-to-left shunting, allowing venous thrombi to enter the arterial circulation: a mechanism known as paradoxical embolism. We present a case of a 51-year-old woman who developed dyspnea, abdominal pain and, a painful swollen leg. Imaging revealed a saddle pulmonary embolism, renal and splenic infarctions and occlusion of the right brachial artery. Echocardiography confirmed the presence of a PFO. Other common sites of paradoxical embolism include the brain, mesenteric circulation, and coronary arteries. In patients with venous thrombosis, clinicians should carefully assess for signs of concomitant arterial embolism: examine the abdomen, evaluate peripheral pulses in the limbs and perform a basic neurological examination. This case highlights the importance of thorough clinical evaluation to ensure timely recognition of this potentially serious condition.
期刊介绍:
Het NTVG staat bekend als hét wetenschappelijke algemene medische tijdschrift. De lange historie en de degelijkheid maken het tijdschrift tot een bolwerk van medische wetenschap in druk. Ook door de goede leesbaarheid draagt het tijdschrift bij aan de voortdurende dialoog over de geneeskunde.