Fungal central nervous system infection caused by non-Candida yeasts and dimorphic fungi following neurosurgical procedures: Iatrogenic or not?

IF 3.5 3区医学 Q3 INFECTIOUS DISEASES

Medical mycology Pub Date : 2026-05-01 DOI:10.1093/mmy/myag034

Chia-Yu Chiu, Rachel S Hicklen, Dimitrios P Kontoyiannis

引用次数: 0

Abstract

Most iatrogenic central nervous system fungal infections (ICNSFIs) are caused by Candida species or molds. However, the ICNSFIs caused by non-Candida yeasts and dimorphic molds have not been evaluated. In the literature review, we identified 24 cases of potential non-Candida yeasts and dimorphic molds-related ICNSFIs, 75% were associated with CNS diversion devices, and 63% were Cryptococcus neoformans infection. The median time from the procedure to the onset of CNS symptoms was 6.5 months. These patients had mild cerebrospinal fluid pleocytosis (median WBC, 12 × 10⁶/l). The 90-day mortality rate was 17%.

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神经外科手术后非念珠菌和二形真菌引起的真菌性中枢神经系统感染：医源性还是非医源性？

大多数医源性中枢神经系统真菌感染（icnsfi）是由念珠菌或霉菌引起的。然而，由非念珠菌和二态霉菌引起的icnsfi尚未得到评价。在文献综述中，我们发现了24例潜在的非念珠菌酵母和二形霉菌相关的icnsfi， 75%与中枢神经系统导流装置有关，63%为新型隐球菌感染。从手术到出现中枢神经系统症状的中位时间为6.5个月。这些患者有轻度脑脊液多胞症（中位白细胞，12 × 10 26 /L）。90天死亡率为17%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical mycology 医学-兽医学

CiteScore

5.70

自引率

3.40%

发文量

632

审稿时长

12 months

期刊介绍： Medical Mycology is a peer-reviewed international journal that focuses on original and innovative basic and applied studies, as well as learned reviews on all aspects of medical, veterinary and environmental mycology as related to disease. The objective is to present the highest quality scientific reports from throughout the world on divergent topics. These topics include the phylogeny of fungal pathogens, epidemiology and public health mycology themes, new approaches in the diagnosis and treatment of mycoses including clinical trials and guidelines, pharmacology and antifungal susceptibilities, changes in taxonomy, description of new or unusual fungi associated with human or animal disease, immunology of fungal infections, vaccinology for prevention of fungal infections, pathogenesis and virulence, and the molecular biology of pathogenic fungi in vitro and in vivo, including genomics, transcriptomics, metabolomics, and proteomics. Case reports are no longer accepted. In addition, studies of natural products showing inhibitory activity against pathogenic fungi are not accepted without chemical characterization and identification of the compounds responsible for the inhibitory activity.