Uncomplicated Cataract Surgery and Neovascular Conversion of Age-Related Macular Degeneration: Fifteen-Year Follow-Up Study.

IF 0.9 Q3 OPHTHALMOLOGY

Journal of Current Ophthalmology Pub Date : 2026-03-18 eCollection Date: 2025-07-01 DOI:10.4103/joco.joco_207_25

Komal Agarwal, Elham Sadeghi, Kunaal Mehrotra, Sandeep Chandra Bollepalli, Kiran Kumar Vupparaboina, Jay Chhablani

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引用次数: 0

Abstract

Purpose: To evaluate the impact of cataract surgery on neovascular age-related macular degeneration (nAMD) conversion over a 15-year follow-up period.

Methods: This 15-year retrospective study on dry AMD patients compared Group A (cataract surgery) and Group B (no surgery). It assessed nAMD conversion rates, mean logMAR best-corrected visual acuity (BCVA), and final central macular thickness (CMT) changes. Kaplan-Meier survival curves and log-rank tests evaluated the impact of cataract surgery on time to conversion.

Results: This study included 73 eyes from 46 patients, with a mean baseline age of 68.78 ± 8.62 years. Among them, 31 (67.39%) were female. Final analyses comprised 43 eyes in Group A and 30 eyes in Group B. Group A had a higher baseline age (70.3 ± 8.58 vs. 65.6 ± 7.24; P = 0.01), but baseline BCVA was similar (0.26 ± 0.33 vs. 0.29 ± 0.40; P = 0.61). The nAMD conversion rate showed no difference (32.55% vs. 36.66%; P = 0.491), as well as mean age at conversion (77.5 ± 8.10 vs. 77 ± 3.66; P = 0.80). The mean interval of conversion from cataract surgery was 5.24 ± 3.22 years. Final logMAR BCVA (0.78 ± 0.73 vs. 0.8 ± 0.76; P = 0.61) and mean CMT at final follow-up (167.6 ± 77.26 vs. 187 ± 85.19; P = 0.90) were also similar. The log-rank test showed no association between cataract surgery and conversion rate (P = 0.789).

Conclusions: The present study did not find a significant difference in conversion from dry to wet AMD between patients who underwent cataract surgery and who did not. No significant difference was noted in the age at the time of conversion between the two groups.

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无并发症白内障手术和老年性黄斑变性新生血管转化：15年随访研究。

目的：评估白内障手术对新生血管性年龄相关性黄斑变性（nAMD）转化的影响，随访15年。方法：对干性黄斑变性患者进行15年回顾性研究，比较A组（白内障手术）和B组（未手术）。它评估了nAMD转化率、平均logMAR最佳矫正视力（BCVA）和最终黄斑中央厚度（CMT）的变化。Kaplan-Meier生存曲线和log-rank检验评估了白内障手术对转复期的影响。结果：本研究纳入46例患者73只眼，平均基线年龄为68.78±8.62岁。其中女性31例（67.39%）。A组患者基线年龄较高（70.3±8.58比65.6±7.24,P = 0.01），但基线BCVA相似（0.26±0.33比0.29±0.40,P = 0.61）。nAMD转换率（32.55%∶36.66%;P = 0.491）和平均年龄（77.5±8.10∶77±3.66;P = 0.80）无显著差异。白内障手术转化的平均时间间隔为5.24±3.22年。最终logMAR BCVA（0.78±0.73 vs 0.8±0.76,P = 0.61）和最终随访时的平均CMT（167.6±77.26 vs 187±85.19,P = 0.90）也相似。log-rank检验显示白内障手术与转换率无相关性（P = 0.789）。结论：本研究未发现干性黄斑变性向湿性黄斑变性在接受白内障手术和未接受白内障手术的患者之间有显著差异。两组患者转换时的年龄差异无统计学意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Current Ophthalmology OPHTHALMOLOGY-

CiteScore

2.50

自引率

6.70%

发文量

审稿时长

8 weeks

期刊介绍： Peer Review under the responsibility of Iranian Society of Ophthalmology Journal of Current Ophthalmology, the official publication of the Iranian Society of Ophthalmology, is a peer-reviewed, open-access, scientific journal that welcomes high quality original articles related to vision science and all fields of ophthalmology. Journal of Current Ophthalmology is the continuum of Iranian Journal of Ophthalmology published since 1969.