Juliana Peres, Jeferson Freitas Toregeani, Ana Julia Vendrametto
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引用次数: 0
Abstract
Background: Postoperative complications in vascular surgery are associated with high morbidity, mortality, and hospital costs, highlighting the need for reliable predictive tools for risk stratification.
Objectives: To develop and validate a clinical model to estimate the risk of postoperative complications in vascular surgery.
Methods: This retrospective study included 510 patients who underwent vascular surgeries between 2021 and 2024, divided into arterial, venous, and vascular access subgroups. Clinical and surgical variables were analyzed using multivariate logistic regression, and model performance was evaluated using the receiver operating characteristic curve.
Results: The overall complication rate was 17.6%, being higher in arterial procedures (35.6%) than venous procedures (11.3%) or vascular access surgeries (6.9%). In the total sample, age (odds ratio [OR] 1.03; p = 0.006), chronic kidney disease (OR 9.94; p < 0.001), smoking (OR 3.29; p = 0.001), and procedure time (p = 0.038) were independent predictors, while chronic anticoagulant use had a protective effect (OR 0.39; p = 0.036). In the specific subgroup models, type 2 diabetes mellitus (OR 13.54; p < 0.001) and chronic kidney disease (OR 15.30; p = 0.007) were significant predictors in the venous access group, smoking was associated with risk in the vascular access group (OR 9.57; p = 0.081), and chronic kidney disease was significant in the arterial group (OR 6.50; p < 0.001). The model showed good discriminatory performance (overall area under the curve [AUC] = 0.806).
Conclusions: The proposed model demonstrated good accuracy and clinical applicability, allowing individualized risk stratification across different vascular surgery contexts. External validation is needed to confirm its usefulness.
背景:血管手术术后并发症与高发病率、死亡率和住院费用相关,因此需要可靠的风险分层预测工具。目的:建立并验证一个评估血管手术术后并发症风险的临床模型。方法:本回顾性研究纳入了2021年至2024年间接受血管手术的510例患者,分为动脉、静脉和血管通路亚组。使用多变量logistic回归分析临床和手术变量,并使用受试者工作特征曲线评估模型的性能。结果:总并发症发生率为17.6%,动脉手术(35.6%)高于静脉手术(11.3%)或血管通路手术(6.9%)。在总样本中,年龄(比值比[OR] 1.03; p = 0.006)、慢性肾脏疾病(比值比[OR] 9.94; p < 0.001)、吸烟(比值比[OR] 3.29; p = 0.001)和手术时间(p = 0.038)是独立的预测因子,而慢性抗凝剂使用具有保护作用(比值比[OR] 0.39; p = 0.036)。在特定亚组模型中,2型糖尿病(OR 13.54, p < 0.001)和慢性肾脏疾病(OR 15.30, p = 0.007)是静脉通路组的显著预测因子,吸烟与血管通路组的风险相关(OR 9.57, p = 0.081),而慢性肾脏疾病在动脉通路组显著(OR 6.50, p < 0.001)。该模型具有良好的判别性能(总体曲线下面积[AUC] = 0.806)。结论:所提出的模型具有良好的准确性和临床适用性,允许在不同血管手术背景下进行个体化风险分层。需要外部验证来确认其有效性。
期刊介绍:
The Jornal Vascular Brasileiro is editated and published quaterly to select and disseminate high-quality scientific contents concerning original research, novel surgical and diagnostic techniques, and clinical observations in the field of vascular surgery, angiology, and endovascular surgery. Its abbreviated title is J. Vasc. Bras., which should be used in bibliographies, footnotes and bibliographical references and strips.