Motoric Cognitive Risk Syndrome among Community-Dwelling Older Adults in China: Prevalence, Associated Factors, and Adverse Outcomes.

IF 3.1 3区医学 Q3 GERIATRICS & GERONTOLOGY

Gerontology Pub Date : 2026-01-01 Epub Date: 2026-04-14 DOI:10.1159/000551825

Hongtao Cheng, Hexiao Ding, Shuangni Huang, Jingyang Zhang, Tianxu Miao, Siyu Zhang, June Zhang

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引用次数: 0

Abstract

Introduction: Motoric cognitive risk syndrome (MCR) is a screening syndrome that has been associated with increased dementia risk in prior studies. This study aimed to investigate the prevalence, associated factors, and adverse outcomes of MCR among community-dwelling older adults in China.

Methods: A cross-sectional analysis was conducted among 5,242 China Health and Retirement Longitudinal Study (CHARLS) participants aged ≥60 years to examine factors associated with prevalent MCR, and prospective outcomes were evaluated over a 3-year follow-up. The Boruta algorithm was used for feature selection. Multivariate logistic regression analysis was employed to assess associations, while XGBoost was applied as a complementary baseline classification approach to rank feature importance for distinguishing prevalent MCR.

Results: The prevalence of MCR was 12.9% among the study population, with higher rates in unmarried, illiterate, and older participants. Physical performance measures emerged as the strongest associated factors, with five-time sit-to-stand test (odds ratio [OR] = 1.05, 95% confidence interval [95% CI]: 1.03-1.07), handgrip strength (OR = 0.98, 95% CI: 0.97-0.99), and mobility score (OR = 1.12, 95% CI: 1.04-1.19) showing significant associations. Higher education level (OR = 0.67, 95% CI: 0.51-0.89) and social activity participation (OR = 0.69, 95% CI: 0.58-0.82) were inversely associated with prevalent MCR, while stroke (OR = 2.18, 95% CI: 1.43-3.24), visual impairment (OR = 1.40, 95% CI: 1.08-1.84), and poor self-reported health status (OR = 1.50, 95% CI: 1.13-2.00) were associated with higher odds of prevalent MCR. MCR was prospectively associated with activities of daily living disability (adjusted OR = 1.40, 95% CI: 1.12-1.73) but not hospitalization (adjusted OR = 1.08, 95% CI: 0.87-1.34).

Conclusion: These findings underscore the importance of incorporating physical performance measures and social factors in MCR screening protocols and may inform screening and risk stratification in aging populations.

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中国社区老年人运动认知风险综合征：患病率、相关因素和不良后果

运动认知风险综合征（MCR）是一种筛查综合征，在先前的研究中与痴呆风险增加有关。本研究旨在调查中国社区老年人MCR的患病率、相关因素和不良结局。方法：对5242名年龄≥60岁的CHARLS参与者进行横断面分析，以检查与MCR流行相关的因素，并在3年随访期间评估前瞻性结果。采用Boruta算法进行特征选择。多变量逻辑回归分析用于评估相关性，而XGBoost被用作补充基线分类方法，对特征重要性进行排序，以区分流行的MCR。结果：MCR在研究人群中的患病率为12.9%，在未婚、文盲和老年参与者中患病率更高。身体表现指标是最强的相关因素，五次坐立测试（OR=1.05, 95%CI: 1.03-1.07）、握力（OR=0.98, 95%CI: 0.97-0.99）和活动能力评分（OR=1.12, 95%CI: 1.04-1.19）显示出显著的相关。高等教育水平（OR=0.67, 95%CI: 0.51-0.89）和社会活动参与（OR=0.69, 95%CI: 0.58-0.82）与MCR患病率呈负相关，而卒中（OR=2.18, 95%CI: 1.43-3.24）、视力障碍（OR=1.40, 95%CI: 1.08-1.84）和自我报告健康状况不佳（OR=1.50, 95%CI: 1.13-2.00）与MCR患病率较高相关。MCR与ADL残疾有前瞻性关联（校正OR=1.40, 95% CI: 1.12-1.73），但与住院无关（校正OR=1.08, 95% CI: 0.87-1.34）。结论：这些发现强调了在MCR筛查方案中纳入身体表现指标和社会因素的重要性，并可能为老年人群的筛查和风险分层提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gerontology 医学-老年医学

CiteScore

6.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： In view of the ever-increasing fraction of elderly people, understanding the mechanisms of aging and age-related diseases has become a matter of urgent necessity. ''Gerontology'', the oldest journal in the field, responds to this need by drawing topical contributions from multiple disciplines to support the fundamental goals of extending active life and enhancing its quality. The range of papers is classified into four sections. In the Clinical Section, the aetiology, pathogenesis, prevention and treatment of agerelated diseases are discussed from a gerontological rather than a geriatric viewpoint. The Experimental Section contains up-to-date contributions from basic gerontological research. Papers dealing with behavioural development and related topics are placed in the Behavioural Science Section. Basic aspects of regeneration in different experimental biological systems as well as in the context of medical applications are dealt with in a special section that also contains information on technological advances for the elderly. Providing a primary source of high-quality papers covering all aspects of aging in humans and animals, ''Gerontology'' serves as an ideal information tool for all readers interested in the topic of aging from a broad perspective.