The global evaluation of the effects of antioxidants on seminal outcomes in infertile men: a systematic review and meta-analysis.

IF 2 4区医学 Q2 OBSTETRICS & GYNECOLOGY

Human Fertility Pub Date : 2026-12-01 Epub Date: 2026-04-15 DOI:10.1080/14647273.2026.2650222

Qinyan Xu, Zhongying Wan, Zhiyuan Xiong, Xiaoyun Zhu, Qin Han, Yiya Wang, Jiayu Zhao, Feihu Yu

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Abstract

The aim of the current review is to summarise information from publications on the impact of antioxidants on seminal outcomes in infertile men. A systematic search was performed in the five valid databases (Scopus, PubMed, Medline, Embase, and Web of Science) utilizing two sets of keywords up to September 2025, according to the PRISMA approach. Of the 11749 papers identified, 101 papers were included in this review, for a total of 11889 infertile men. Sperm concentration, normal sperm morphology, progressive sperm motility, and total sperm motility, were considerably higher in experimental groups compared with control groups. Both sperm concentration (10⁶ mL^-1) and total motility (%) were higher in experimental groups compared to control groups with an overall pooled standardised mean difference (SMD) of 2.33 (95% CI: 1.73, 2.94) for sperm concentration and SMD of 1.62 (95% CI: 1.20, 2.04) for total motility (%). Subgroup analysis demonstrated that duration of treatments of more than 6 months were more effective than those of less than 3 months. Based on the findings of this review, no definitive recommendation can be made regarding the use of antioxidants as a therapy for male infertility, and further research is necessary.

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抗氧化剂对不育男性精子结局影响的全球评估：系统回顾和荟萃分析。

本综述的目的是总结关于抗氧化剂对不育男性生殖结果影响的出版物中的信息。根据PRISMA方法，系统检索了截至2025年9月的5个有效数据库（Scopus、PubMed、Medline、Embase和Web of Science），使用了两组关键词。在确定的11749篇论文中，101篇论文被纳入本综述，共涉及11889名不育男性。与对照组相比，实验组的精子浓度、正常精子形态、精子运动能力和总精子运动能力显著提高。实验组的精子浓度（106 mL-1）和总活动力（%）均高于对照组，精子浓度的总体合并标准化平均差（SMD）为2.33 (95% CI: 1.73, 2.94)，总活动力（%）的SMD为1.62 （95% CI: 1.20, 2.04）。亚组分析显示，治疗时间超过6个月者比治疗时间少于3个月者更有效。基于这篇综述的发现，对于使用抗氧化剂治疗男性不育症没有明确的建议，进一步的研究是必要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human Fertility OBSTETRICS & GYNECOLOGY-REPRODUCTIVE BIOLOGY

CiteScore

3.30

自引率

5.30%

发文量

期刊介绍： Human Fertility is a leading international, multidisciplinary journal dedicated to furthering research and promoting good practice in the areas of human fertility and infertility. Topics included span the range from molecular medicine to healthcare delivery, and contributions are welcomed from professionals and academics from the spectrum of disciplines concerned with human fertility. It is published on behalf of the British Fertility Society. The journal also provides a forum for the publication of peer-reviewed articles arising out of the activities of the Association of Biomedical Andrologists, the Association of Clinical Embryologists, the Association of Irish Clinical Embryologists, the British Andrology Society, the British Infertility Counselling Association, the Irish Fertility Society and the Royal College of Nursing Fertility Nurses Group. All submissions are welcome. Articles considered include original papers, reviews, policy statements, commentaries, debates, correspondence, and reports of sessions at meetings. The journal also publishes refereed abstracts from the meetings of the constituent organizations.