The associations between resting and total energy expenditure, physical activity, and thyroid hormone levels in adult females.

IF 3.2 3区医学 Q2 PHYSIOLOGY

Frontiers in Physiology Pub Date : 2026-03-31 eCollection Date: 2026-01-01 DOI:10.3389/fphys.2026.1716140

S A Sanduni Samudika De Alwis, Xueying Zhang, Huihui Mei, Xinyi Bi, Xinyue Ma, Ying Liu, Li Xue, Dehuang Kong, Lu Wang, Hongbo Wang, John R Speakman

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引用次数: 0

Abstract

Introduction: Physical activity (PA) costs energy. However, recent theory suggests the relationship of increasing PA to total energy expenditure (TEE) is non-linear because high levels of activity suppress resting metabolism mediated via changes in thyroid hormones (THs; T3- triiodothyronine, T4- thyroxine, fT3- free triiodothyronine, fT4 - free thyroxine, TSH - thyroid stimulating hormone).

Method: We conducted a cross-sectional study on 38 euthyroid females (NCT06377943) to examine the relationship between PA, resting metabolic rate (RMR), and TEE. Multiple linear regression and Bootstrapped structural equation model were used to assessed whether THs statistically accounted for the association between PA and RMR.

Results: Bootstrapped structural equation models indicated that PA was significantly associated with lower TH levels (β = -4.33, 95% CI [-8.51, -1.70], p = 0.011), while the association between THs and RMR was small and non-significant (β = 0.043, 95% CI [-0.02, 0.10], p = 0.16), resulting in a non-significant indirect effect (β = -0.19, 95% CI [-0.67, 0.08], p = 0.31). In multiple regression plots, physical activity energy expenditure (PAEE) and PA showed a trend toward significance (p = 0.07) when THs were added.

Conclusion: Overall, although PA was associated with modest changes in THs, these changes did not correspond to any detectable decrease in RMR.

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成年女性静息与总能量消耗、体力活动和甲状腺激素水平之间的关系。

体育活动（PA）消耗能量。然而，最近的理论表明，PA增加与总能量消耗（TEE）的关系是非线性的，因为高水平的活动抑制了通过甲状腺激素（THs； T3-三碘甲状腺原氨酸，T4-甲状腺素，不含fT3的三碘甲状腺原氨酸，不含fT4的甲状腺素，TSH -促甲状腺激素）变化介导的静息代谢。方法：对38例甲状腺功能正常的女性（NCT06377943）进行横断面研究，探讨PA、静息代谢率（RMR）和TEE之间的关系。使用多元线性回归和bootstrap结构方程模型来评估这是否在统计学上解释了PA与RMR之间的关联。结果：自举结构方程模型显示，PA与较低TH水平显著相关（β = -4.33, 95% CI [-8.51, -1.70], p = 0.011），而TH与RMR之间的相关性较小且不显著（β = 0.043, 95% CI [-0.02, 0.10], p = 0.16），间接效应不显著（β = -0.19, 95% CI [-0.67, 0.08], p = 0.31）。在多元回归图中，体力活动能量消耗（PAEE）和体力活动能量消耗（PA）在加入THs后呈显著性趋势（p = 0.07）。结论：总体而言，尽管PA与THs的适度变化相关，但这些变化并不对应于任何可检测到的RMR下降。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Physiology PHYSIOLOGY-

CiteScore

6.50

自引率

5.00%

发文量

2608

审稿时长

14 weeks

期刊介绍： Frontiers in Physiology is a leading journal in its field, publishing rigorously peer-reviewed research on the physiology of living systems, from the subcellular and molecular domains to the intact organism, and its interaction with the environment. Field Chief Editor George E. Billman at the Ohio State University Columbus is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.