Late-Onset Hypoparathyroidism-Induced Hypocalcemia in a Very Low Birth Weight Infant Caused by Undiagnosed Maternal Hyperparathyroidism.

IF 0.6 Q4 PEDIATRICS

AJP Reports Pub Date : 2026-04-14 eCollection Date: 2026-04-01 DOI:10.1055/a-2837-6826

Arne Beyer, Meike Franssen, Kai Böckenholt, Jonas Rohde, Ester Domning, Florian Schneider

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Abstract

Objective: To describe a rare case of late-onset neonatal hypocalcemia in a very preterm infant caused by maternal adenoma-related hyperparathyroidism (HyperPT) and to discuss diagnostic and therapeutic implications.

Study design: Case report of a preterm infant born at 29 weeks of gestation with very low birth weight. Clinical course, laboratory findings, maternal history, and management were reviewed to identify the etiology and guide treatment.

Results: The infant developed transient, asymptomatic hypocalcemia during the neonatal period. Maternal evaluation revealed primary HyperPT due to a parathyroid adenoma as the underlying cause. The newborn responded to calcium supplementation and optimized vitamin D therapy.

Conclusion: Maternal HyperPT can cause delayed neonatal hypocalcemia even in preterm infants. Early recognition through coordinated maternal-neonatal evaluation is crucial. Optimal vitamin D administration and close interdisciplinary communication between obstetrics and neonatology are essential for prevention and management.

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未确诊的母亲甲状旁腺功能亢进引起的迟发性甲状旁腺功能低下引起的极低出生体重婴儿低钙血症。

目的：报道一例罕见的由母体腺瘤相关性甲状旁腺功能亢进（HyperPT）引起的迟发性新生儿低钙症，并探讨其诊断和治疗意义。研究设计：一例妊娠29周早产婴儿出生体重极低的病例报告。临床过程，实验室结果，产妇病史和管理回顾，以确定病因和指导治疗。结果：患儿在新生儿期出现暂时性无症状的低钙血症。母体评估显示原发性甲状腺旁腺腺瘤为潜在病因。新生儿对补钙和优化的维生素D治疗有反应。结论：产妇高pt可引起迟发性新生儿低钙血症，即使是早产儿。通过协调的母婴评估进行早期识别至关重要。优化维生素D管理和密切产科和新生儿之间的跨学科沟通是预防和管理的必要条件。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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