Dual electrochemical sensor based on graphene aerogel for quantification of ascorbic acid in pharmaceutical samples and uric acid in urine

IF 2 4区化学 Q3 CHEMISTRY, ANALYTICAL

Analytical Sciences Pub Date : 2026-04-15 DOI:10.1007/s44211-026-00896-z

Alejandro Gutiérrez, Mario Sánchez-Suárez, Natalia Rey-Raap, Ana Arenillas, Janet Ledesma-García, Luis Gerardo Arriaga

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Abstract

This work presents the advantages of modifying glassy carbon electrodes with a graphene aerogel (GA) dispersed in polyethylenimine (PEI). The presence of GA entrapped in PEI produces a catalytic effect that greatly facilitates the separation of the anodic peaks of ascorbic acid (AA) and uric acid (UA), enabling their detection and quantification by differential pulse voltammetry (DPV). The result is a highly efficient dual electrochemical sensor with a sensitivity of approximately 2.13 × 10⁴ µAM^− 1 for AA and 5.0 × 10⁴ µAM^− 1 UA. The current response showed a linear relationship for AA when the concentration ranged from 1.0 to 10 × 10^− 4 M, with a minimum detection concentration of 0.25 µM and a relative standard deviation (RSD) of 2.0%. For UA, the lineal range was 1.0–15.0 × 10^− 5 M, with a minimum detection concentration of 9 µM and an RSD of 2.8%. The promising analytical performance, which allows the evaluation of AA and UA, enables accurate quantification of AA in pharmaceutical samples and UA in urine without the use of enzymes or pretreatment.

AbstractSection Graphical abstract

The alternative text for this image may have been generated using AI.

Abstract Image

查看原文本刊更多论文

基于石墨烯气凝胶的双电化学传感器用于定量药物样品中的抗坏血酸和尿液中的尿酸。

这项工作提出了用分散在聚乙烯亚胺（PEI）中的石墨烯气凝胶（GA）修饰玻碳电极的优点。被PEI捕获的GA的存在产生了催化作用，极大地促进了抗坏血酸（AA）和尿酸（UA）的阳极峰的分离，从而可以通过差分脉冲伏安法（DPV）对其进行检测和定量。结果是一个高效的双电化学传感器，灵敏度约为2.13 × 104 μ AM−1 AA和5.0 × 104 μ AM−1 UA。在1.0 ~ 10 × 10−4 M范围内，AA电流响应呈线性关系，最小检测浓度为0.25µM，相对标准偏差（RSD）为2.0%。UA的线性范围为1.0 ~ 15.0 × 10−5 M，最小检测浓度为9µM， RSD为2.8%。该方法具有良好的分析性能，可对AA和UA进行评价，可在不使用酶或预处理的情况下准确定量药物样品中的AA和尿液中的UA。此图像的替代文本可能是使用AI生成的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Analytical Sciences 化学-分析化学

CiteScore

2.90

自引率

18.80%

发文量

232

审稿时长

1 months

期刊介绍： Analytical Sciences is an international journal published monthly by The Japan Society for Analytical Chemistry. The journal publishes papers on all aspects of the theory and practice of analytical sciences, including fundamental and applied, inorganic and organic, wet chemical and instrumental methods. This publication is supported in part by the Grant-in-Aid for Publication of Scientific Research Result of the Japanese Ministry of Education, Culture, Sports, Science and Technology.