Protective Effect and Mechanism of Nanofiber Membrane Loaded With Curcumin Inclusion Compound in Periodontitis Oxidative Stress

IF 4.9 4区工程技术 Q1 BIOCHEMICAL RESEARCH METHODS

IET nanobiotechnology Pub Date : 2026-03-31 DOI:10.1049/nbt2/6679414

Xinting Yang, Yingjie Xu, Shulong Guan, Ming Xu, Tengyu Ma, Yuanping Hao, Xinru Yang, Meihua Gao, Wanchun Wang, Yuguang Gao, Yuanfei Wang, Beibei Cong

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Abstract

Periodontitis, a leading cause of tooth loss, is conventionally treated by mechanical curettage and antibiotics, which may cause adverse effects. Curcumin (Cur), a natural anti-inflammatory and antioxidant agent, shows therapeutic potential but suffers from low solubility and bioavailability. To overcome these limitations, we developed an electrospun nanofiber membrane (HP-Cur-IC/poly-L-lactone-co-ε-caprolactone [PLCL]) containing cyclodextrin-encapsulated Cur for localized sustained drug delivery within periodontal pockets. The resulting membrane exhibited improved water solubility, mechanical strength, and drug release profile. It demonstrated significant antioxidant and antibacterial effects, as evidenced by reductions in oxidative stress markers and bacterial viability. Furthermore, the membrane modulated the JAK2/STAT3 and ERK/JNK/p38 signaling pathways, alleviating oxidative damage in periodontal tissues. These findings suggest that the HP-Cur-IC/PLCL nanofiber membrane represents a promising nonsurgical strategy for periodontitis treatment.

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姜黄素包合物纳米纤维膜对牙周炎氧化应激的保护作用及其机制

牙周炎是导致牙齿脱落的主要原因，传统的治疗方法是机械刮除和抗生素，这可能会导致不良反应。姜黄素（Curcumin, Cur）是一种天然的抗炎和抗氧化剂，具有治疗潜力，但其溶解度和生物利用度较低。为了克服这些局限性，我们开发了一种含有环糊精包封Cur的电纺丝纳米纤维膜（hp - cu - ic /聚l -内酯-co-ε-己内酯[PLCL]），用于在牙周袋内局部持续给药。所得膜具有更好的水溶性、机械强度和药物释放特性。它具有显著的抗氧化和抗菌作用，氧化应激标志物和细菌活力的降低证明了这一点。此外，该膜调节JAK2/STAT3和ERK/JNK/p38信号通路，减轻牙周组织的氧化损伤。这些发现表明，hp - cu - ic /PLCL纳米纤维膜是非手术治疗牙周炎的一种很有前途的策略。

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来源期刊

IET nanobiotechnology 工程技术-纳米科技

CiteScore

6.20

自引率

4.30%

发文量

审稿时长

1 months

期刊介绍： Electrical and electronic engineers have a long and illustrious history of contributing new theories and technologies to the biomedical sciences. This includes the cable theory for understanding the transmission of electrical signals in nerve axons and muscle fibres; dielectric techniques that advanced the understanding of cell membrane structures and membrane ion channels; electron and atomic force microscopy for investigating cells at the molecular level. Other engineering disciplines, along with contributions from the biological, chemical, materials and physical sciences, continue to provide groundbreaking contributions to this subject at the molecular and submolecular level. Our subject now extends from single molecule measurements using scanning probe techniques, through to interactions between cells and microstructures, micro- and nano-fluidics, and aspects of lab-on-chip technologies. The primary aim of IET Nanobiotechnology is to provide a vital resource for academic and industrial researchers operating in this exciting cross-disciplinary activity. We can only achieve this by publishing cutting edge research papers and expert review articles from the international engineering and scientific community. To attract such contributions we will exercise a commitment to our authors by ensuring that their manuscripts receive rapid constructive peer opinions and feedback across interdisciplinary boundaries. IET Nanobiotechnology covers all aspects of research and emerging technologies including, but not limited to: Fundamental theories and concepts applied to biomedical-related devices and methods at the micro- and nano-scale (including methods that employ electrokinetic, electrohydrodynamic, and optical trapping techniques) Micromachining and microfabrication tools and techniques applied to the top-down approach to nanobiotechnology Nanomachining and nanofabrication tools and techniques directed towards biomedical and biotechnological applications (e.g. applications of atomic force microscopy, scanning probe microscopy and related tools) Colloid chemistry applied to nanobiotechnology (e.g. cosmetics, suntan lotions, bio-active nanoparticles) Biosynthesis (also known as green synthesis) of nanoparticles; to be considered for publication, research papers in this area must be directed principally towards biomedical research and especially if they encompass in vivo models or proofs of concept. We welcome papers that are application-orientated or offer new concepts of substantial biomedical importance Techniques for probing cell physiology, cell adhesion sites and cell-cell communication Molecular self-assembly, including concepts of supramolecular chemistry, molecular recognition, and DNA nanotechnology Societal issues such as health and the environment Special issues. Call for papers: Smart Nanobiosensors for Next-generation Biomedical Applications - https://digital-library.theiet.org/files/IET_NBT_CFP_SNNBA.pdf Selected extended papers from the International conference of the 19th Asian BioCeramic Symposium - https://digital-library.theiet.org/files/IET_NBT_CFP_ABS.pdf