Jixu Lu, Jing Chen, Ji Zhu, Lixin Ru, Dongxiao Zhang
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引用次数: 0
Abstract
Radiotherapy and chemotherapy are widely employed in cancer treatment but frequently induce intestinal toxicity, which significantly compromises patients’ quality of life and limits therapeutic efficacy. Polyphenols, a diverse class of natural compounds with broad biological activities, have demonstrated protective effects against radio/chemotherapy-induced intestinal injury through antioxidation, anti-inflammation, DNA damage repair, and microbiota modulation, etc. However, the limited stability, bioavailability, and targeting efficiency of polyphenols hinder their oral use in clinical practice. This review summarizes the mechanisms and oral delivery challenges of polyphenols. Furthermore, it highlights recent advances in oral delivery systems designed to address the oral limitations of polyphenols. Challenges in developing such systems and potential future directions are also discussed, aiming to provide new perspectives for oral polyphenol formulations to prevent/treat radio/chemotherapy-induced intestinal toxicity.
期刊介绍：
Advanced NanoBiomed Research will provide an Open Access home for cutting-edge nanomedicine, bioengineering and biomaterials research aimed at improving human health. The journal will capture a broad spectrum of research from increasingly multi- and interdisciplinary fields of the traditional areas of biomedicine, bioengineering and health-related materials science as well as precision and personalized medicine, drug delivery, and artificial intelligence-driven health science.
The scope of Advanced NanoBiomed Research will cover the following key subject areas:
▪ Nanomedicine and nanotechnology, with applications in drug and gene delivery, diagnostics, theranostics, photothermal and photodynamic therapy and multimodal imaging.
▪ Biomaterials, including hydrogels, 2D materials, biopolymers, composites, biodegradable materials, biohybrids and biomimetics (such as artificial cells, exosomes and extracellular vesicles), as well as all organic and inorganic materials for biomedical applications.
▪ Biointerfaces, such as anti-microbial surfaces and coatings, as well as interfaces for cellular engineering, immunoengineering and 3D cell culture.
▪ Biofabrication including (bio)inks and technologies, towards generation of functional tissues and organs.
▪ Tissue engineering and regenerative medicine, including scaffolds and scaffold-free approaches, for bone, ligament, muscle, skin, neural, cardiac tissue engineering and tissue vascularization.
▪ Devices for healthcare applications, disease modelling and treatment, such as diagnostics, lab-on-a-chip, organs-on-a-chip, bioMEMS, bioelectronics, wearables, actuators, soft robotics, and intelligent drug delivery systems.
with a strong focus on applications of these fields, from bench-to-bedside, for treatment of all diseases and disorders, such as infectious, autoimmune, cardiovascular and metabolic diseases, neurological disorders and cancer; including pharmacology and toxicology studies.
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