C. R. Ríos-Soberanis, V. M. Moo-Huchin, E. Pérez-Pacheco
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引用次数: 0
Abstract
The objective of this study was to develop and optimize orally disintegrating films (ODFs) incorporating an ethanolic extract of Apis mellifera propolis as a natural source of antioxidants. A mixture design was applied to evaluate the combined effect of propolis, essential oil, and polymers on the functional properties of the films. The extract exhibited a high content of phenolic compounds (318.15 ± 5.76 mg GAE/g) and flavonoids (644.82 ± 6.41 mg QE/g), along with strong antioxidant activity (DPPH 87.43%, ABTS 91.12%). The optimal formulation achieved a significant balance between mechanical properties (tensile strength 6.21 MPa, elongation 15.84%) and antioxidant activity, accomplishing a comprehensive improvement through propolis-polymer interaction. The quadratic models obtained were significant (R2 > 0.74). These results demonstrate the potential of propolis-containing ODFs as functional polymeric materials for rapid release systems with bioactive properties.
期刊介绍：
ChemistrySelect is the latest journal from ChemPubSoc Europe and Wiley-VCH. It offers researchers a quality society-owned journal in which to publish their work in all areas of chemistry. Manuscripts are evaluated by active researchers to ensure they add meaningfully to the scientific literature, and those accepted are processed quickly to ensure rapid online publication.
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