Biological Properties of Glycerohydrogels Based on a Mixture of Chitosan Hydrochloride with Glucomannan, Formed In Situ on the Wound Surface

IF 1.1 4区生物学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Applied Biochemistry and Microbiology Pub Date : 2026-04-16 DOI:10.1134/S0003683825602057

O. N. Malinkina, D. V. Pridankina, A. S. Astankova, A. B. Shipovskaya

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Abstract

Hybrid hydrogels formed in situ on the wound surface are considered promising materials for reconstruction and therapy. This paper examines the dermo- ex vivo and mucoadhesive properties in vitro, as well as the antibacterial, hemostatic, and wound-healing activity in vitro and in vivo of glycerohydrogels based on chitosan hydrochloride, glucomannan, silicon tetraglycerolate (a sol-gel precursor), and functional additives. When applied to an intact or wounded dermal surface, the gel-forming composition results in the formation of a protective glycerohydrogel coating (gel film) with explicit adhesive and sorption properties forms in situ within 3–5 minutes. This coating exhibits bacteriostatic and haemostatic action, as well as wound-healing activity. In vivo evaluation of the wound-healing effect showed a statistically significant reduction in skin restoration time compared to the control, allowing us to recommend glycerohydrogel films as effective bioresorbable wound dressings.

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基于盐酸壳聚糖与葡甘露聚糖混合物在创面原位形成的甘油水凝胶的生物学特性

在创面原位形成的杂化水凝胶被认为是有前景的重建和治疗材料。本文研究了以盐酸壳聚糖、葡甘露聚糖、四甘油酯硅（一种溶胶-凝胶前体）和功能添加剂为基础的甘油水凝胶的体外皮肤和体外黏附性能，以及体外和体内的抗菌、止血和伤口愈合活性。当应用于完整或受伤的皮肤表面时，凝胶形成组合物可在3-5分钟内形成具有明显粘附和吸附特性的保护性甘油水凝胶涂层（凝胶膜）。这种涂层具有抑菌和止血作用，以及伤口愈合活性。对伤口愈合效果的体内评估显示，与对照组相比，皮肤恢复时间有统计学意义上的显著减少，这使我们能够推荐甘油水凝胶薄膜作为有效的生物可吸收伤口敷料。

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来源期刊

Applied Biochemistry and Microbiology 生物-生物工程与应用微生物

CiteScore

1.70

自引率

12.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Applied Biochemistry and Microbiology is an international peer reviewed journal that publishes original articles on biochemistry and microbiology that have or may have practical applications. The studies include: enzymes and mechanisms of enzymatic reactions, biosynthesis of low and high molecular physiologically active compounds; the studies of their structure and properties; biogenesis and pathways of their regulation; metabolism of producers of biologically active compounds, biocatalysis in organic synthesis, applied genetics of microorganisms, applied enzymology; protein and metabolic engineering, biochemical bases of phytoimmunity, applied aspects of biochemical and immunochemical analysis; biodegradation of xenobiotics; biosensors; biomedical research (without clinical studies). Along with experimental works, the journal publishes descriptions of novel research techniques and reviews on selected topics.