Cellular and molecular mechanisms of systemic sclerosis: Translation to targeted therapies and clinical practice.

IF 4.8 2区医学 Q1 RHEUMATOLOGY

Best Practice & Research in Clinical Rheumatology Pub Date : 2026-04-12 DOI:10.1016/j.berh.2026.102137

Diane Documet, Sophia Ruser, Crystal Cheung, Monique Hinchcliff, Manvitha Nadella

引用次数: 0

Abstract

Systemic sclerosis (SSc) is characterized by profound clinical heterogeneity due to dysregulated communication between vascular, immune, and stromal compartments. This review synthesizes genetic and epigenetic determinants of SSc with observations from transcriptomic, proteomic, and metabolomic studies. We highlight emerging cellular- and molecular-level insights into vasculopathy, immune dysregulation, and fibroblast activation in SSc. Finally, we discuss how these mechanistic discoveries inform the development of targeted, precision-medicine based therapeutic approaches in SSc.

查看原文本刊更多论文

系统性硬化症的细胞和分子机制：转化为靶向治疗和临床实践。

系统性硬化症（SSc）的特点是由于血管、免疫和间质室之间的沟通失调，导致临床异质性严重。本文通过转录组学、蛋白质组学和代谢组学的研究，综合了SSc的遗传和表观遗传决定因素。我们强调了SSc中血管病变、免疫失调和成纤维细胞激活的细胞和分子水平的新见解。最后，我们讨论了这些机制发现如何为SSc的靶向、精准医学治疗方法的发展提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Best Practice & Research in Clinical Rheumatology 医学-风湿病学

CiteScore

9.40

自引率

0.00%

发文量

审稿时长

27 days

期刊介绍： Evidence-based updates of best clinical practice across the spectrum of musculoskeletal conditions. Best Practice & Research: Clinical Rheumatology keeps the clinician or trainee informed of the latest developments and current recommended practice in the rapidly advancing fields of musculoskeletal conditions and science. The series provides a continuous update of current clinical practice. It is a topical serial publication that covers the spectrum of musculoskeletal conditions in a 4-year cycle. Each topic-based issue contains around 200 pages of practical, evidence-based review articles, which integrate the results from the latest original research with current clinical practice and thinking to provide a continuous update. Each issue follows a problem-orientated approach that focuses on the key questions to be addressed, clearly defining what is known and not known. The review articles seek to address the clinical issues of diagnosis, treatment and patient management. Management is described in practical terms so that it can be applied to the individual patient. The serial is aimed at the physician in both practice and training.