The amount of the settled surfactant dipalmitoylphosphatidylcholine (DPPC) in the heart of rats does not correlate with decompression illness.

IF 0.6 4区医学 Q4 MARINE & FRESHWATER BIOLOGY

Undersea and Hyperbaric Medicine Pub Date : 2026-01-01

Uri Wolkowski, Soliman Khatib, Ran Arieli

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引用次数: 0

Abstract

Introduction: The lung surfactant dipalmitoylphosphatidylcholine (DPPC) settles on the luminal aspect of blood vessels to form active hydrophobic spots (AHS). The nanobubbles that develop at these spots are gas micronuclei from which decompression bubbles expand upon decompression. Variability between "bubblers" and "non-bubblers" is derived from the variability in the AHS. We expected that the level of DPPC in the heart would correlate with the severity of decompression illness (DCI).

Methods: Thirty-six rats were exposed to 8 bar for 32 minutes.

Results: After decompression, they were examined for DCI and defined as non-DCI rats (ND, n=18), DCI-inflicted rats (DCI, n=13), and dead rats (DEATH, n=5). The DPPC concentration in the hearts (mg/g) was 2.97 ± 0.56 SD for ND, 2.87 ± 0.62 SD for DCI, and 2.81 ± 0.46 SD for DEATH.

Discussion: There was no significant difference between the three groups. The results are discussed, and a further study to explore the correlation between bubbling and heart DPPC is suggested.

本刊更多论文

表面活性剂双棕榈酰磷脂酰胆碱（DPPC）在大鼠心脏中的沉降量与减压病无关。

肺表面活性物质双棕榈酰磷脂酰胆碱（DPPC）在血管腔面形成活性疏水点（AHS）。在这些地方形成的纳米气泡是气体微核，减压气泡在减压时膨胀。“起泡器”和“非起泡器”之间的差异源于AHS的可变性。我们预计心脏中DPPC的水平与减压病（DCI）的严重程度相关。方法：36只大鼠8 bar暴露32 min。结果：减压后进行DCI检查，定义为非DCI大鼠（ND, n=18）、DCI致伤大鼠（DCI, n=13）和死亡大鼠（DEATH, n=5）。心内DPPC浓度（mg/g） ND组为2.97±0.56 SD， DCI组为2.87±0.62 SD， DEATH组为2.81±0.46 SD。讨论：三组间无显著性差异。讨论了这些结果，并建议进一步研究鼓泡与心脏DPPC的相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Undersea and Hyperbaric Medicine 医学-海洋与淡水生物学

CiteScore

1.60

自引率

11.10%

发文量

审稿时长

>12 weeks

期刊介绍： Undersea and Hyperbaric Medicine Journal accepts manuscripts for publication that are related to the areas of diving research and physiology, hyperbaric medicine and oxygen therapy, submarine medicine, naval medicine and clinical research related to the above topics. To be considered for UHM scientific papers must deal with significant and new research in an area related to biological, physical and clinical phenomena related to the above environments.