Transmission patterns of pertussis in school-based clustered outbreaks: A retrospective analysis in Zhejiang Province, China, 2024.

IF 4.2 4区医学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Human Vaccines & Immunotherapeutics Pub Date : 2026-12-31 Epub Date: 2026-04-14 DOI:10.1080/21645515.2026.2654305

Shuhan Zheng, Feng Luo, Hangjie Zhang, Yang Zhou, Ying Su, Hanqing He, Yao Zhu

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Abstract

We conducted a retrospective study using data from Zhejiang Province's pertussis surveillance system between February 1 and May 1, 2024, defining school-based clusters as ≥5 cases occurring within 21 d in the same class. We identified 124 outbreaks involving 825 confirmed cases, with cluster sizes ranging from 5 to 16 cases (median: 7). Most outbreaks occurred in primary schools (79.03%, 98/124), followed by kindergartens (19.35%, 24/124) and middle schools (1.61%, 2/124). Among cases, 19.3% (159/825) were index cases (predominantly aged 7-8 y) and 80.7% (666/825) were secondary infections. The median serial interval was 9.0 d (IQR: 5.0-13.0); it was significantly longer in kindergarten than in primary school cases (10.0 vs. 9.0 d, P = .007) and shorter with earlier diagnosis (7-14 d post-onset) (7.0 vs 10.0 d, P = .007). Our findings emphasize the importance of protecting high-risk school populations, implementing prompt outbreak control measures, and conducting timely health education to prevent pertussis transmission.

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以学校为基础的聚集性百日咳疫情传播模式：中国浙江省2024年回顾性分析

我们利用浙江省2024年2月1日至5月1日百日咳监测系统的数据进行了回顾性研究，将以学校为基础的聚集性病例定义为在21天内同一班级发生≥5例病例。我们确定了124次疫情，涉及825例确诊病例，集群规模从5到16例不等（中位数：7）。疫情以小学为主（79.03%,98/124），其次为幼儿园（19.35%,24/124）和中学（1.61%,2/124）。其中，指数型感染占19.3%(159/825)，以7 ~ 8岁为主，继发感染占80.7%（666/825）。中位序列间隔为9.0 d (IQR: 5.0-13.0)；幼稚园患者的时间明显长于小学患者(10.0 d vs. 9.0 d, P =。越早诊断（发病后7-14 d），时间越短（7.0 vs 10.0 d, P = .007）。我们的研究结果强调了保护学校高危人群、及时实施疫情控制措施和及时开展健康教育以预防百日咳传播的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human Vaccines & Immunotherapeutics BIOTECHNOLOGY & APPLIED MICROBIOLOGY-IMMUNOLOGY

CiteScore

7.90

自引率

8.30%

发文量

489

审稿时长

3-6 weeks

期刊介绍： (formerly Human Vaccines; issn 1554-8619) Vaccine research and development is extending its reach beyond the prevention of bacterial or viral diseases. There are experimental vaccines for immunotherapeutic purposes and for applications outside of infectious diseases, in diverse fields such as cancer, autoimmunity, allergy, Alzheimer’s and addiction. Many of these vaccines and immunotherapeutics should become available in the next two decades, with consequent benefit for human health. Continued advancement in this field will benefit from a forum that can (A) help to promote interest by keeping investigators updated, and (B) enable an exchange of ideas regarding the latest progress in the many topics pertaining to vaccines and immunotherapeutics. Human Vaccines & Immunotherapeutics provides such a forum. It is published monthly in a format that is accessible to a wide international audience in the academic, industrial and public sectors.