Piotr Michałowski, Katarzyna Rynarzewska, Dagmara Nowicka, Olimpia Gawrońska, Katarzyna Bielicka-Daszkiewicz
{"title":"Fungal secondary metabolites as a source of bioactive compounds: a modern approach to their acquisition and analysis","authors":"Piotr Michałowski, Katarzyna Rynarzewska, Dagmara Nowicka, Olimpia Gawrońska, Katarzyna Bielicka-Daszkiewicz","doi":"10.18388/2dqryt92","DOIUrl":null,"url":null,"abstract":"<p><p>Secondary metabolites, which are natural products of fungi, perform key biological functions and have applications in medicine. The production of these compounds is subject to the control of clusters of biosynthetic genes located within the genome. It has been observed that these genes can become dormant under standard culture conditions. The advent of modern genetic and epigenetic methodologies has rendered the activation of these elements possible, thus facilitating the identification of novel bioactive compounds. The present article delineates classes of metabolites, the mechanisms of their biosynthesis, and current research strategies, combining knowledge from biology, genetics, and biotechnology.</p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"72 1","pages":"23-36"},"PeriodicalIF":0.0000,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Postepy biochemii","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18388/2dqryt92","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Secondary metabolites, which are natural products of fungi, perform key biological functions and have applications in medicine. The production of these compounds is subject to the control of clusters of biosynthetic genes located within the genome. It has been observed that these genes can become dormant under standard culture conditions. The advent of modern genetic and epigenetic methodologies has rendered the activation of these elements possible, thus facilitating the identification of novel bioactive compounds. The present article delineates classes of metabolites, the mechanisms of their biosynthesis, and current research strategies, combining knowledge from biology, genetics, and biotechnology.
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