Paincontrol: identity-preserving pain expression transfer with generative diffusion models.

IF 4.6 4区 医学 Q3 ENGINEERING, BIOMEDICAL
Yasamin Zarghami, Muhammad Muzammil, Vida Adeli, Hailey Reimer, Thomas Hadjistavropoulos, Babak Taati
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引用次数: 0

Abstract

Automated pain detection models rely on large, diverse facial expression datasets; yet pain expression data are scarce due to privacy concerns and ethical constraints. This study explores synthetic pain expression generation as a potential solution, investigating whether expression transfer methods are sufficiently accurate to expand training sets by transferring expressions from a limited set of real data to a virtually unlimited set of identities. This work represents an initial step toward the use of privacy-preserving generative AI for synthetic data generation to improve in pain detection. We introduce PainControl, a novel facial landmark-guided method for identity-preserving pain expression transfer. Rather than using motion signals from video, as in prior methods, our method adapts a ControlNet approach, using text and dense facial landmarks to control fine-grained facial muscle activations while maintaining identity consistency through image embeddings. Identity preservation enables the generation of demographically diverse datasets, improving generalizability across populations. We compare PainControl to existing expression transfer methods and evaluate (i) perceptual realism, (ii) identity preservation, (iii) facial action unit (AU) transfer accuracy, and (iv) downstream pain detection performance. Our model produces realistic synthetic pain expressions, outperforming baselines in human-rated Likert-scale assessments. However, AU transfer analysis reveals challenges in accurately synthesizing expression intensities-particularly for AU4 (Brow Lowering) and AU43 (Eye Closure), which are crucial for pain recognition. When used to augment real pain datasets, synthetic images did not improve classifier performance, likely due to artifacts, AU misalignment, and the lack of temporal motion cues. Critically, however, our experiments in data-scarce regimes, where real pain expressions are extremely limited, demonstrate that synthetic augmentation through PainControl provides significant and consistent performance gains for pain detection models. These results validate that our ControlNet-based approach has reached sufficient maturity and accuracy to serve as a reliable data augmentation tool in pain detection domains, particularly in scenarios, where acquiring real data are prohibitively difficult or ethically constrained. This finding establishes the practical viability of expression transfer methods for addressing the fundamental data scarcity challenge in affective computing and clinical pain assessment. These results highlight both the promise and current limitations of generative models for pain expression, pointing to future research in AU alignment and temporal modeling for clinical-grade applications.

疼痛控制:基于生成扩散模型的身份保留疼痛表达转移。
自动疼痛检测模型依赖于大量不同的面部表情数据集;然而,由于隐私问题和道德约束,疼痛表达数据很少。本研究探讨了合成疼痛表情生成作为一种潜在的解决方案,研究了表情转移方法是否足够准确,可以通过将表情从有限的真实数据集转移到几乎无限的身份集来扩展训练集。这项工作代表了在合成数据生成中使用隐私保护生成人工智能以改善疼痛检测的第一步。我们介绍了一种新的面部地标引导方法PainControl,用于保持身份的疼痛表情转移。与之前的方法不同,我们的方法采用了ControlNet方法,使用文本和密集的面部标志来控制细粒度的面部肌肉激活,同时通过图像嵌入保持身份一致性。身份保存可以生成人口统计学上不同的数据集,提高跨人群的普遍性。我们将PainControl与现有的表情转移方法进行了比较,并评估了(i)感知真实感,(ii)身份保留,(iii)面部动作单元(AU)转移准确性,以及(iv)下游疼痛检测性能。我们的模型产生真实的合成疼痛表达,优于人类评定的李克特量表评估基线。然而,AU转移分析揭示了准确合成表达强度的挑战,特别是AU4(眉毛下垂)和AU43(闭眼),它们对疼痛识别至关重要。当用于增强真实疼痛数据集时,合成图像并没有提高分类器的性能,可能是由于伪影、AU不对齐和缺乏时间运动线索。然而,关键的是,我们在数据稀缺的情况下的实验,真实的疼痛表达非常有限,表明通过PainControl的合成增强为疼痛检测模型提供了显著和一致的性能提升。这些结果验证了我们基于controlnet的方法已经达到了足够的成熟度和准确性,可以作为疼痛检测领域可靠的数据增强工具,特别是在获取真实数据非常困难或道德约束的情况下。这一发现确立了表达转移方法在情感计算和临床疼痛评估中解决基本数据稀缺挑战的实际可行性。这些结果突出了疼痛表达生成模型的前景和当前的局限性,指出了临床级应用的AU对齐和时间建模的未来研究。
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来源期刊
BioMedical Engineering OnLine
BioMedical Engineering OnLine 工程技术-工程:生物医学
CiteScore
6.70
自引率
2.60%
发文量
79
审稿时长
1 months
期刊介绍: BioMedical Engineering OnLine is an open access, peer-reviewed journal that is dedicated to publishing research in all areas of biomedical engineering. BioMedical Engineering OnLine is aimed at readers and authors throughout the world, with an interest in using tools of the physical and data sciences and techniques in engineering to understand and solve problems in the biological and medical sciences. Topical areas include, but are not limited to: Bioinformatics- Bioinstrumentation- Biomechanics- Biomedical Devices & Instrumentation- Biomedical Signal Processing- Healthcare Information Systems- Human Dynamics- Neural Engineering- Rehabilitation Engineering- Biomaterials- Biomedical Imaging & Image Processing- BioMEMS and On-Chip Devices- Bio-Micro/Nano Technologies- Biomolecular Engineering- Biosensors- Cardiovascular Systems Engineering- Cellular Engineering- Clinical Engineering- Computational Biology- Drug Delivery Technologies- Modeling Methodologies- Nanomaterials and Nanotechnology in Biomedicine- Respiratory Systems Engineering- Robotics in Medicine- Systems and Synthetic Biology- Systems Biology- Telemedicine/Smartphone Applications in Medicine- Therapeutic Systems, Devices and Technologies- Tissue Engineering
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