The role of Klotho protein in delaying cellular ageing through exercise intervention: SA - β - Gal activity and age-related metabolism.

IF 3.2 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Archives of Physiology and Biochemistry Pub Date : 2026-04-13 DOI:10.1080/13813455.2026.2657414

Jiangtao Xie, Shan Luo

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引用次数: 0

Abstract

Background: Cellular ageing is closely related to various age-related diseases, and Klotho protein, as an anti-ageing related factor, plays an important role in delaying ageing by regulating cellular function and metabolism.

Purpose: This study aims to explore the role of Klotho protein in exercise intervention and its relationship with age-related metabolism.

Methods: Study the effects of exercise intervention on serum Klotho protein levels, Klotho gene methylation status, ageing related β - galactosidase (SA - β - Gal) activity, and ageing metabolic indicators, revealing the molecular mechanism of exercise delaying cellular ageing. The experiment was divided into a control group and an exercise intervention group, with an intervention period of 12 weeks.

Results: Exercise intervention significantly improved oxidative stress indicators and blood lipid metabolism.

Conclusion: Exercise intervention delays cellular ageing by upregulating serum Klotho protein levels and reducing gene methylation levels, inhibiting SA - β - Gal activity, improving oxidative stress and lipid metabolism.

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Klotho蛋白通过运动干预延缓细胞衰老的作用：SA - β - Gal活性和年龄相关代谢。

背景：细胞衰老与各种年龄相关疾病密切相关，Klotho蛋白作为抗衰老相关因子，通过调节细胞功能和代谢，起到延缓衰老的重要作用。目的：探讨Klotho蛋白在运动干预中的作用及其与年龄相关代谢的关系。方法：研究运动干预对血清Klotho蛋白水平、Klotho基因甲基化状态、衰老相关β -半乳糖苷酶（SA - β - Gal）活性及衰老代谢指标的影响，揭示运动延缓细胞衰老的分子机制。实验分为对照组和运动干预组，干预期为12周。结果：运动干预可显著改善氧化应激指标和血脂代谢。结论：运动干预通过上调血清Klotho蛋白水平和降低基因甲基化水平，抑制SA - β - Gal活性，改善氧化应激和脂质代谢，延缓细胞衰老。

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来源期刊

Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY

CiteScore

6.90

自引率

3.30%

发文量

期刊介绍： Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.