{"title":"New secondary metabolites isolated from <i>Streptomyces</i> species.","authors":"William J Price Cunliffe, Peter J Rutledge","doi":"10.1039/d5np00069f","DOIUrl":null,"url":null,"abstract":"<p><p>Covering: 2021 to 2024<i>Streptomyces</i> species have long been recognised as prolific sources of novel natural products, generating a wide array of clinically-relevant antimicrobial and cytotoxic compounds. In this review, we examine 174 publications from 2021 to 2024 that describe 716 previously unreported secondary metabolites isolated from <i>Streptomyces</i> strains sourced from a range of marine and terrestrial environments. Natural product researchers used a variety of chemical and biological techniques, including genome mining, molecular networking, and heterologous expression, to uncover novel compounds with a diverse array of structures, including cyclic and linear peptides, macrocyclic, polyaromatic, and other polyketides, terpenoids, alkaloids, and azoxy compounds, among others. The variety of bioactivities exhibited by these secondary metabolites, including antibacterial, anticancer, antifungal, antiviral, and anti-inflammatory effects, illustrates the enduring potential of the <i>Streptomyces</i> genus to produce promising new bioactive natural products.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":"1308-1344"},"PeriodicalIF":12.5000,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Reports","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d5np00069f","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Covering: 2021 to 2024Streptomyces species have long been recognised as prolific sources of novel natural products, generating a wide array of clinically-relevant antimicrobial and cytotoxic compounds. In this review, we examine 174 publications from 2021 to 2024 that describe 716 previously unreported secondary metabolites isolated from Streptomyces strains sourced from a range of marine and terrestrial environments. Natural product researchers used a variety of chemical and biological techniques, including genome mining, molecular networking, and heterologous expression, to uncover novel compounds with a diverse array of structures, including cyclic and linear peptides, macrocyclic, polyaromatic, and other polyketides, terpenoids, alkaloids, and azoxy compounds, among others. The variety of bioactivities exhibited by these secondary metabolites, including antibacterial, anticancer, antifungal, antiviral, and anti-inflammatory effects, illustrates the enduring potential of the Streptomyces genus to produce promising new bioactive natural products.
期刊介绍：
Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis.
With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results.
NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.
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