{"title":"Front Cover: Substrate Scope Expansion of Tryptophan Synthase for the Chemo-Enzymatic Synthesis of Non-Canonical Tryptophans (ChemCatChem 7/2026)","authors":"Celeste Nobbio, Dario Allevi, Antonia Iazzetti, Giancarlo Fabrizi, Antonella Goggiamani, Davide Tessaro, Fabio Parmeggiani","doi":"10.1002/cctc.70733","DOIUrl":null,"url":null,"abstract":"<p><b>The Front Cover</b> shows the 3D structure of the enzyme tryptophan synthase (TrpS) from <i>Salmonella enterica</i> serovar typhimurium, a versatile and efficient biocatalyst for the production of substituted L-tryptophans from indoles and L-serine. The already broad substrate scope of the enzyme has been further expanded in the Research Article by F. Parmeggiani and co-workers (DOI: 10.1002/cctc.202501808) to afford a range of non-natural tryptophans bearing substituents such as aryl rings, <i>N</i>-methylamino groups, alkynes, and halogens, as depicted in the background.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":141,"journal":{"name":"ChemCatChem","volume":"18 7","pages":""},"PeriodicalIF":3.9000,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/cctc.70733","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemCatChem","FirstCategoryId":"92","ListUrlMain":"https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cctc.70733","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
The Front Cover shows the 3D structure of the enzyme tryptophan synthase (TrpS) from Salmonella enterica serovar typhimurium, a versatile and efficient biocatalyst for the production of substituted L-tryptophans from indoles and L-serine. The already broad substrate scope of the enzyme has been further expanded in the Research Article by F. Parmeggiani and co-workers (DOI: 10.1002/cctc.202501808) to afford a range of non-natural tryptophans bearing substituents such as aryl rings, N-methylamino groups, alkynes, and halogens, as depicted in the background.
期刊介绍：
With an impact factor of 4.495 (2018), ChemCatChem is one of the premier journals in the field of catalysis. The journal provides primary research papers and critical secondary information on heterogeneous, homogeneous and bio- and nanocatalysis. The journal is well placed to strengthen cross-communication within between these communities. Its authors and readers come from academia, the chemical industry, and government laboratories across the world. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and is supported by the German Catalysis Society.
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