Antibiotic use in equine hospitals—Serial point prevalence surveys in six European hospitals

IF 0.8 4区农林科学 Q3 VETERINARY SCIENCES

Equine Veterinary Education Pub Date : 2026-04-01 Epub Date: 2025-07-02 DOI:10.1111/eve.14190

T. S. Mair, C. Sinclair, H. Stone, I. Schofield

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引用次数: 0

Abstract

Background

Monitoring antibiotic use (AMU) is a key component of antimicrobial stewardship. Published AMU data in equine hospitals are limited.

Objectives

To document AMU in equine hospitals.

Study Design

Repeated point prevalence surveys.

Methods

Prospective descriptive study. AMU recorded 1 day weekly for 12 months in six equine hospitals.

Results

One thousand one hundred and forty-two horses were prescribed antibiotics among 15,031 horses (7.6%) hospitalised on 216 survey days. Commonest breeds were Thoroughbreds/crosses (34.7%) and Warmbloods/crosses (22.5%). Median age of adults was 6 years (interquartile range [IQR]: 10, range: 1–28 years) and 8 weeks for foals (IQR: 14 weeks, range: 1 day to 50 weeks). Mean weight of 1127 horses 420 kg (range: 15–866 kg). Commonest indications were complicated wounds (23.6%), gastrointestinal/abdominal disease (19.2%), surgical prophylaxis (15.0%) and simple wounds (11.8%); 81.4% were community-acquired conditions, 14.4% surgical prophylaxis, 3.6% healthcare-acquired. Culture and susceptability performed in 11.4%. The commonest antibiotics prescribed were procaine penicillin (41.8%), gentamicin (41.4%), potentiated sulfonamides (16.5%), oxytetracycline (10.2%), ceftiofur (9.2%) and doxycycline (8.2%). Enrofloxacin prescribed in 59 horses (5.2%) and marbofloxacin in 19 (1.7%). The mean antibiotic dosages (mg/kg bwt) (±SD) were the following: procaine penicillin 20.5 (±2.8), gentamicin 7.1 (±1.0), potentiated sulfonamides 30.4 (±3.0), oxytetracycline 5.9 (±1.0), ceftiofur 5.2 (±1.4), doxycycline 5.9 (±1.7), enrofloxacin 6.6 (±1.1) and marbofloxacin 3.7 (±1.4).

Main Limitations

Systemic AMU only. The duration of antimicrobial courses not recorded. Some cases may have been double (or more)-counted if they were in the hospital on more than 1 survey days.

Conclusions

Antimicrobials were prescribed in 7.6% of hospitalised horses. Commonest indications were complicated wounds, gastrointestinal/abdominal disease, surgical prophylaxis and simple wounds. Commonest antibiotics administered were procaine penicillin, gentamicin, potentiated sulfonamides, oxytetracycline, ceftiofur and doxycycline. Critically important antimicrobial use was uncommon. Dose rates were generally appropriate.

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马医院的抗生素使用- 6家欧洲医院的连续点流行率调查

抗生素使用监测（AMU）是抗菌药物管理的关键组成部分。马医院发表的AMU数据有限。目的记录马医院的AMU。研究设计：重复点患病率调查。方法前瞻性描述性研究。在6家马医院，AMU记录每周1天，持续12个月。结果216天住院治疗的15031匹马中，有1242匹马使用抗生素，占7.6%。最常见的品种是纯种马/杂交（34.7%）和温血马/杂交（22.5%）。成年马的中位年龄为6岁（四分位数间距[IQR]: 10岁，范围为1 - 28岁），马驹的中位年龄为8周（IQR: 14周，范围：1天至50周）。1127匹马平均体重420公斤（范围：15-866公斤）。最常见的指征是复杂伤口（23.6%）、胃肠道/腹腔疾病（19.2%）、手术预防（15.0%）和单纯性伤口（11.8%）；81.4%为社区获得性疾病，14.4%为手术预防，3.6%为卫生保健获得性疾病。文化和易感性占11.4%。最常见的抗生素处方是普鲁卡因青霉素（41.8%）、庆大霉素（41.4%）、增效磺胺类药物（16.5%）、土霉素（10.2%）、头孢替弗（9.2%）和强力霉素（8.2%）。59匹马使用恩诺沙星（5.2%），19匹马使用马氟沙星（1.7%）。抗生素平均剂量（mg/kg bwt）（±SD）如下：普鲁卡因青霉素20.5（±2.8），庆大霉素7.1（±1.0），磺胺类药物30.4（±3.0），土霉素5.9（±1.0），头孢替福5.2（±1.4），强力霉素5.9（±1.7），恩诺沙星6.6（±1.1），马布沙星3.7（±1.4）。仅限系统AMU。抗菌疗程的持续时间未记录。有些病例如果住院超过1天，可能会被双倍（或更多）计算。结论7.6%的住院马使用了抗微生物药物。最常见的适应症是复杂伤口、胃肠/腹腔疾病、手术预防和单纯性伤口。最常用的抗生素是普鲁卡因、青霉素、庆大霉素、强化磺胺类药物、土霉素、头孢替弗和强力霉素。至关重要的抗菌药物的使用并不常见。剂量率一般是适当的。

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来源期刊

Equine Veterinary Education 农林科学-兽医学

CiteScore

2.40

自引率

22.20%

发文量

132

审稿时长

18-36 weeks

期刊介绍： Equine Veterinary Education (EVE) is the official journal of post-graduate education of both the British Equine Veterinary Association (BEVA) and the American Association of Equine Practitioners (AAEP). Equine Veterinary Education is a monthly, peer-reviewed, subscription-based journal, integrating clinical research papers, review articles and case reports from international sources, covering all aspects of medicine and surgery relating to equids. These papers facilitate the dissemination and implementation of new ideas and techniques relating to clinical veterinary practice, with the ultimate aim of promoting best practice. New developments are placed in perspective, encompassing new concepts and peer commentary. The target audience is veterinarians primarily engaged in the practise of equine medicine and surgery. The educational value of a submitted article is one of the most important criteria that are assessed when deciding whether to accept it for publication. Articles do not necessarily need to contain original or novel information but we welcome submission of this material. The educational value of an article may relate to articles published with it (e.g. a Case Report may not have direct educational value but an associated Clinical Commentary or Review Article published alongside it will enhance the educational value).