Autoimmune gastritis: emerging insights and clinical management.

IF 51 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Nature Reviews Gastroenterology &Hepatology Pub Date : 2026-04-13 DOI:10.1038/s41575-026-01200-0

Marco Vincenzo Lenti,Emanuela Miceli,Alessandro Vanoli,Antonio Di Sabatino

{"title":"Autoimmune gastritis: emerging insights and clinical management.","authors":"Marco Vincenzo Lenti,Emanuela Miceli,Alessandro Vanoli,Antonio Di Sabatino","doi":"10.1038/s41575-026-01200-0","DOIUrl":null,"url":null,"abstract":"Autoimmune gastritis (AIG) is an immune-mediated condition that affects the oxyntic mucosa of the stomach, leading to progressive atrophy and deficiencies in vitamin B12, iron and other micronutrients. Our understanding of the pathogenesis, clinical manifestations and management of AIG has improved in the past 20 years. Initially thought to be associated mainly with pernicious anaemia and limited to certain geographical areas, AIG is now recognized as a global disorder with a broad clinical spectrum, ranging from asymptomatic cases to gastrointestinal, haematological, neurological and gynaecological manifestations. The role of Helicobacter pylori in the development of AIG has been debated, with evidence suggesting that AIG might arise through distinct pathogenic pathways both related and unrelated to H. pylori infection. The risk of gastric adenocarcinoma in AIG has also been reassessed on the basis of studies exploring its natural history. Finally, novel insights have emerged regarding the characterization of 'potential AIG' and 'seronegative AIG', two distinct conditions that were previously overlooked. In this Review, we discuss the latest advances in the field of AIG.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"134 1","pages":""},"PeriodicalIF":51.0000,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Gastroenterology &Hepatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41575-026-01200-0","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Autoimmune gastritis (AIG) is an immune-mediated condition that affects the oxyntic mucosa of the stomach, leading to progressive atrophy and deficiencies in vitamin B12, iron and other micronutrients. Our understanding of the pathogenesis, clinical manifestations and management of AIG has improved in the past 20 years. Initially thought to be associated mainly with pernicious anaemia and limited to certain geographical areas, AIG is now recognized as a global disorder with a broad clinical spectrum, ranging from asymptomatic cases to gastrointestinal, haematological, neurological and gynaecological manifestations. The role of Helicobacter pylori in the development of AIG has been debated, with evidence suggesting that AIG might arise through distinct pathogenic pathways both related and unrelated to H. pylori infection. The risk of gastric adenocarcinoma in AIG has also been reassessed on the basis of studies exploring its natural history. Finally, novel insights have emerged regarding the characterization of 'potential AIG' and 'seronegative AIG', two distinct conditions that were previously overlooked. In this Review, we discuss the latest advances in the field of AIG.

查看原文本刊更多论文

自身免疫性胃炎：新见解和临床管理。

自身免疫性胃炎（AIG）是一种免疫介导的疾病，影响胃的氧合粘膜，导致进行性萎缩和维生素B12、铁和其他微量营养素的缺乏。在过去的20年里，我们对AIG的发病机制、临床表现和治疗的认识有所提高。AIG最初被认为主要与恶性贫血有关，仅限于某些地理区域，但现在被认为是一种全球性疾病，具有广泛的临床症状，从无症状病例到胃肠道、血液学、神经学和妇科表现。幽门螺杆菌在AIG发展中的作用一直存在争议，有证据表明AIG可能通过与幽门螺杆菌感染相关或无关的不同致病途径发生。在探索其自然历史的基础上，对AIG的胃腺癌风险也进行了重新评估。最后，关于“潜在AIG”和“血清阴性AIG”的特征，出现了新的见解，这是两个不同的条件，以前被忽视。本文就AIG领域的最新研究进展作一综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nature Reviews Gastroenterology &Hepatology 医学-胃肠肝病学

CiteScore

52.30

自引率

0.60%

发文量

147

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Gastroenterology & Hepatology aims to serve as the leading resource for Reviews and commentaries within the scientific and medical communities it caters to. The journal strives to maintain authority, accessibility, and clarity in its published articles, which are complemented by easily understandable figures, tables, and other display items. Dedicated to providing exceptional service to authors, referees, and readers, the editorial team works diligently to maximize the usefulness and impact of each publication. The journal encompasses a wide range of content types, including Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements, all pertinent to gastroenterologists and hepatologists. With its broad scope, Nature Reviews Gastroenterology & Hepatology ensures that its articles reach a diverse audience, aiming for the widest possible dissemination of valuable information. Nature Reviews Gastroenterology & Hepatology is part of the Nature Reviews portfolio of journals.