Information Transmission in Quorum Sensing for Gut Microbiome

IF 2.5 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC

IEEE Transactions on Molecular, Biological, and Multi-Scale Communications Pub Date : 2026-01-01 Epub Date: 2026-03-24 DOI:10.1109/TMBMC.2026.3677248

O. Tansel Baydas;Efe Yatgin;Ozgur B. Akan

引用次数: 0

Abstract

Microorganisms employ sophisticated mechanisms for intercellular communication and environmental sensing, with quorum sensing serving as a fundamental regulatory process. Dysregulation of quorum sensing has been implicated in various diseases. While most theoretical studies focus on mathematical modeling of quorum sensing dynamics, the communication-theoretic aspects remain less explored. In this study, we investigate the information processing capabilities of quorum sensing systems using a stochastic differential equation framework that links intracellular gene regulation to extracellular autoinducer dynamics. We quantify mutual information as a measure of signaling efficiency and information fidelity in two major bacterial phyla of the gut microbiota: Firmicutes and Bacteroidetes.

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肠道微生物群体感应中的信息传递

微生物采用复杂的细胞间通讯和环境感知机制，群体感知是一个基本的调节过程。群体感应失调与多种疾病有关。虽然大多数理论研究集中在群体感应动力学的数学建模上，但通信理论方面的探索仍然较少。在这项研究中，我们使用随机微分方程框架来研究群体感应系统的信息处理能力，该框架将细胞内基因调控与细胞外自诱导剂动力学联系起来。我们将相互信息量化为肠道微生物群中两个主要细菌门：厚壁菌门和拟杆菌门的信号效率和信息保真度的衡量标准。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

IEEE Transactions on Molecular, Biological, and Multi-Scale Communications Mathematics-Modeling and Simulation

CiteScore

3.90

自引率

13.60%

发文量

期刊介绍： As a result of recent advances in MEMS/NEMS and systems biology, as well as the emergence of synthetic bacteria and lab/process-on-a-chip techniques, it is now possible to design chemical “circuits”, custom organisms, micro/nanoscale swarms of devices, and a host of other new systems. This success opens up a new frontier for interdisciplinary communications techniques using chemistry, biology, and other principles that have not been considered in the communications literature. The IEEE Transactions on Molecular, Biological, and Multi-Scale Communications (T-MBMSC) is devoted to the principles, design, and analysis of communication systems that use physics beyond classical electromagnetism. This includes molecular, quantum, and other physical, chemical and biological techniques; as well as new communication techniques at small scales or across multiple scales (e.g., nano to micro to macro; note that strictly nanoscale systems, 1-100 nm, are outside the scope of this journal). Original research articles on one or more of the following topics are within scope: mathematical modeling, information/communication and network theoretic analysis, standardization and industrial applications, and analytical or experimental studies on communication processes or networks in biology. Contributions on related topics may also be considered for publication. Contributions from researchers outside the IEEE’s typical audience are encouraged.