Synthesis and biological activity of 2-SF5-pyridyl substituted analogs of commercial neonicotinoid insecticides Sulfoxaflor, Flupyradifurone, Imidacloprid and Thiamethoxam

IF 1.6 4区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Fluorine Chemistry Pub Date : 2026-04-01 DOI:10.1016/j.jfluchem.2026.110565

Oleksandr S. Kanishchev , Andrew J.F. Edmunds , Peter Maienfisch , William R. Dolbier Jr

引用次数: 0

Abstract

In this paper, we report synthesis and bioactivity studies of four 2-SF₅-pyridyl substituted analogs of commercial neonicotinoid insecticides. Despite many known examples when substitution of CF₃-group with SF₅-group can enhance bioactivity profile of the target molecule, we have discovered that in the series of 2-SF₅-pyridyl analogs of Sulfoxaflor, Flupyradifurone, Imidacloprid and Thiamethoxam that substitution did not lead to any improvement in biological activity as compared to trifluoromethyl- and/or chloro‑substituted congeners.

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新烟碱类商品杀虫剂亚砜、氟吡喃酮、吡虫啉和噻虫嗪的2- sf5 -吡啶取代类似物的合成及生物活性

本文报道了4种2- sf5 -吡啶基取代新烟碱类杀虫剂类似物的合成及生物活性研究。尽管有许多已知的例子表明，用sf5取代cf3基团可以增强目标分子的生物活性，但我们发现，与三氟甲基和/或氯取代的同系物相比，在亚砜、氟吡喃酮、吡虫啉和噻虫嗪的2- sf5 -吡啶基类似物系列中，取代并没有导致生物活性的任何改善。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Fluorine Chemistry 化学-无机化学与核化学

CiteScore

3.80

自引率

10.50%

发文量

审稿时长

33 days

期刊介绍： The Journal of Fluorine Chemistry contains reviews, original papers and short communications. The journal covers all aspects of pure and applied research on the chemistry as well as on the applications of fluorine, and of compounds or materials where fluorine exercises significant effects. This can include all chemistry research areas (inorganic, organic, organometallic, macromolecular and physical chemistry) but also includes papers on biological/biochemical related aspects of Fluorine chemistry as well as medicinal, agrochemical and pharmacological research. The Journal of Fluorine Chemistry also publishes environmental and industrial papers dealing with aspects of Fluorine chemistry on energy and material sciences. Preparative and physico-chemical investigations as well as theoretical, structural and mechanistic aspects are covered. The Journal, however, does not accept work of purely routine nature. For reviews and special issues on particular topics of fluorine chemistry or from selected symposia, please contact the Regional Editors for further details.