Enhancement of Orthodontic Tooth Movement by Oral Administration of Pangasius hypophthalmus Oil: An In Vivo Study

IF 2.7 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Orthodontics & Craniofacial Research Pub Date : 2026-08-18 Epub Date: 2026-04-10 DOI:10.1111/ocr.70123

Hilda Fitria Lubis, Erik Idrus, Dewi Fatma Suniarti Sastradipura, Sugeng Heri Suseno, Retno Widayati, Lisa Rinanda Amir, Anton Bahtiar, Fadli Jazaldi, Pitu Wulandari

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引用次数: 0

Abstract

Background

Enhancing orthodontic tooth movement is a crucial aspect in reducing the duration of treatment. This study aims to investigate the potential of Pangasius hypophthalmus oil in promoting tooth movement in rabbits.

Materials and Methods

Forty-eight male rabbits were employed in four experimental groups (n = 12 per group): Group 1 served as the control, while Groups 2, 3, and 4 received oral doses of Pangasius hypophthalmus oil at concentrations of 250 mg/kg body weight, 500 mg/kg body weight, and 1,000 mg/kg body weight, respectively. Orthodontic appliances were placed between the lower central incisors of the rabbits, applying an orthodontic force of 100 g/mm². The oil was administered orally to the rabbits every day for 14 days. Specimens were euthanised on day 1, 3, 7, or 14 according to the experimental group, and immunohistochemical analysis was conducted to evaluate TRAP and OPN expression in alveolar bone at compression sites.

Results

The administration of Pangasius hypophthalmus oil with a dose of 1,000 mg/kg body weight led to the highest increase of orthodontic movement, indicated by a rise of TRAP and OPN expression compared to other concentrations (p < 0.05).

Conclusion

The Pangasius hypophthalmus oil has the potent ability to increase the orthodontic tooth movement, indicated by the rise in TRAP and OPN expression.

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口服巴沙鱼低眼油增强正畸牙齿运动的体内研究。

背景：提高正畸牙齿的运动是减少治疗时间的关键方面。本研究旨在探讨下眼棘鱼油对家兔牙齿运动的促进作用。材料与方法：雄性家兔48只，分为4个实验组（每组12只）：第1组为对照组，第2、3、4组分别口服浓度为250 mg/kg、500 mg/kg、1000 mg/kg的巴沙鱼低眼油。正畸矫治器放置于兔下正中门牙之间，施加100 g/mm2的正畸力。每日口服精油，连续14 d。实验组分别于第1天、第3天、第7天和第14天对标本实施安乐死，并通过免疫组织化学分析评估受压部位牙槽骨中TRAP和OPN的表达。结果：以1000 mg/kg体重给药的巴沙鱼下眼油对正畸牙齿运动的促进作用最大，表现为TRAP和OPN表达的升高(p)。结论：巴沙鱼下眼油对正畸牙齿运动具有明显的促进作用，表现为TRAP和OPN表达的升高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Orthodontics & Craniofacial Research 医学-牙科与口腔外科

CiteScore

5.30

自引率

3.20%

发文量

审稿时长

>12 weeks

期刊介绍： Orthodontics & Craniofacial Research - Genes, Growth and Development is published to serve its readers as an international forum for the presentation and critical discussion of issues pertinent to the advancement of the specialty of orthodontics and the evidence-based knowledge of craniofacial growth and development. This forum is based on scientifically supported information, but also includes minority and conflicting opinions. The objective of the journal is to facilitate effective communication between the research community and practicing clinicians. Original papers of high scientific quality that report the findings of clinical trials, clinical epidemiology, and novel therapeutic or diagnostic approaches are appropriate submissions. Similarly, we welcome papers in genetics, developmental biology, syndromology, surgery, speech and hearing, and other biomedical disciplines related to clinical orthodontics and normal and abnormal craniofacial growth and development. In addition to original and basic research, the journal publishes concise reviews, case reports of substantial value, invited essays, letters, and announcements. The journal is published quarterly. The review of submitted papers will be coordinated by the editor and members of the editorial board. It is policy to review manuscripts within 3 to 4 weeks of receipt and to publish within 3 to 6 months of acceptance.