Study on the mechanism of AMPK protein macromolecules in relieving exercise fatigue: AMPK protein signalling pathway.

IF 3.2 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Archives of Physiology and Biochemistry Pub Date : 2026-04-10 DOI:10.1080/13813455.2026.2657422

Lei Wenjuan, Yang Jie

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引用次数: 0

Abstract

Background: Exercise fatigue is an important factor affecting exercise performance and recovery. Studies have found that AMPK (adenosine monophosphate activated protein kinase) plays a key role in energy metabolism and exercise adaptation.

Purpose: The study aims to explore role of AMPK protein macromolecules in alleviating exercise fatigue and the characteristics of their signalling pathways.

Methods: This article uses a rat model for experiments, extracts and detects RNA from muscle tissue, and uses real-time fluorescence quantitative PCR to analyse the expression level of AMPK and evaluate its activation status. By analysing the expression effect of AMPK related protein signalling pathway, explore its impact on exercise fatigue.

Results: The exercise intervention group of rats regulated by AMPK showed significant improvement in exercise fatigue, significant increase in energy metabolism indicators, and enhanced immune function.

Conclusion: The results indicate that AMPK protein macromolecules effectively alleviate exercise fatigue and improve energy metabolism and immune function by activating related signalling pathways.

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AMPK蛋白大分子缓解运动性疲劳的机制研究：AMPK蛋白信号通路。

背景：运动疲劳是影响运动表现和恢复的重要因素。研究发现AMPK（腺苷单磷酸活化蛋白激酶）在能量代谢和运动适应中起着关键作用。目的：探讨AMPK蛋白大分子在缓解运动性疲劳中的作用及其信号通路的特点。方法：采用大鼠模型进行实验，从肌肉组织中提取并检测RNA，采用实时荧光定量PCR分析AMPK的表达水平，评价其激活状态。通过分析AMPK相关蛋白信号通路的表达效果，探讨其对运动性疲劳的影响。结果：AMPK调节的运动干预组大鼠运动疲劳明显改善，能量代谢指标明显升高，免疫功能增强。结论：AMPK蛋白大分子通过激活相关信号通路，有效缓解运动性疲劳，改善能量代谢和免疫功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY

CiteScore

6.90

自引率

3.30%

发文量

期刊介绍： Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.