{"title":"Short-Term Antioxidant Effects of Vitamin E-Coated Filters During Continuous Kidney Replacement Therapy in Critically Ill Patients.","authors":"Masahiro Kawamura, Masafumi Fukuda, Nobuhisa Hirayu, Masakazu Nabeta, Keisuke Yoshida, Osamu Yamaga, Kei Fukami, Osamu Takasu, Norio Yamashita","doi":"10.1002/1744-9987.70135","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to assess the short-term antioxidant effects of a vitamin E-coated membrane during continuous kidney replacement therapy (CKRT) based on the neutrophil-to-lymphocyte ratio (NLR) and red cell distribution width (RDW).</p><p><strong>Methods: </strong>CKRT sessions conducted between December 2023 and May 2025 at a single tertiary-care center were retrospectively analyzed. Based on the type of hemofilter used, sessions were categorized into polysulfone membrane (PS) and vitamin E-coated membrane (VE) groups. Laboratory parameters at CKRT initiation and 48 h thereafter were compared between the two groups.</p><p><strong>Results: </strong>Overall, 79 CKRT sessions (33 patients) were analyzed. In the PS group, NLR and RDW-SD increased significantly (p < 0.01 and p = 0.03), whereas no significant changes were observed in the VE group.</p><p><strong>Conclusion: </strong>Vitamin E-coated membranes may exert short-term antioxidant effects during CKRT by reducing inflammatory and oxidative responses as reflected by NLR and RDW.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"530-535"},"PeriodicalIF":1.2000,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/1744-9987.70135","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/4/9 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Introduction: This study aimed to assess the short-term antioxidant effects of a vitamin E-coated membrane during continuous kidney replacement therapy (CKRT) based on the neutrophil-to-lymphocyte ratio (NLR) and red cell distribution width (RDW).
Methods: CKRT sessions conducted between December 2023 and May 2025 at a single tertiary-care center were retrospectively analyzed. Based on the type of hemofilter used, sessions were categorized into polysulfone membrane (PS) and vitamin E-coated membrane (VE) groups. Laboratory parameters at CKRT initiation and 48 h thereafter were compared between the two groups.
Results: Overall, 79 CKRT sessions (33 patients) were analyzed. In the PS group, NLR and RDW-SD increased significantly (p < 0.01 and p = 0.03), whereas no significant changes were observed in the VE group.
Conclusion: Vitamin E-coated membranes may exert short-term antioxidant effects during CKRT by reducing inflammatory and oxidative responses as reflected by NLR and RDW.
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