{"title":"\"Bilateral Nigral Hyperintensity Sign\" in Epstein-Barr Virus Encephalitis.","authors":"Sabeeha Naaz, Bhavani Madduluri, Surya Prabha Turaga, Yoshitha Balam, Arun Siddaiah","doi":"10.4103/jgid.jgid_103_25","DOIUrl":null,"url":null,"abstract":"<p><p>Epstein-Barr virus (EBV) encephalitis is a rare cause of encephalitis in India and has no pathognomic imaging findings described. Here, we describe the case of a 17-year-old male with fever, cerebellitis, and extrapyramidal involvement, followed by altered sensorium. Imaging showed T2/fluid-attenuated inversion recovery bilaterally symmetric hyperintensities with diffusion restriction in substantia nigra. Cerebrospinal fluid analysis and polymerase chain reaction were positive for EBV. Magnetic resonance imaging findings in EBV encephalitis are known to occur in cortical, subcortical regions, white matter, basal ganglia, thalamus, brain stem, and cerebellum. Isolated involvement of substantia nigra is less reported in the literature. Hence, this case highlights the clinical radiological correlation that can be seen in EBV encephalitis with secondary parkinsonism. The patient recovered after starting antivirals, steroids, and other symptomatic treatments.</p>","PeriodicalId":51581,"journal":{"name":"Journal of Global Infectious Diseases","volume":"18 1","pages":"45-47"},"PeriodicalIF":1.1000,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13061142/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Global Infectious Diseases","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/jgid.jgid_103_25","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0
Abstract
Epstein-Barr virus (EBV) encephalitis is a rare cause of encephalitis in India and has no pathognomic imaging findings described. Here, we describe the case of a 17-year-old male with fever, cerebellitis, and extrapyramidal involvement, followed by altered sensorium. Imaging showed T2/fluid-attenuated inversion recovery bilaterally symmetric hyperintensities with diffusion restriction in substantia nigra. Cerebrospinal fluid analysis and polymerase chain reaction were positive for EBV. Magnetic resonance imaging findings in EBV encephalitis are known to occur in cortical, subcortical regions, white matter, basal ganglia, thalamus, brain stem, and cerebellum. Isolated involvement of substantia nigra is less reported in the literature. Hence, this case highlights the clinical radiological correlation that can be seen in EBV encephalitis with secondary parkinsonism. The patient recovered after starting antivirals, steroids, and other symptomatic treatments.
期刊介绍：
JGID encourages research, education and dissemination of knowledge in the field of Infectious Diseases across the world thus promoting translational research by striking a synergy between basic science, clinical medicine and public health. The Journal intends to bring together scientists and academicians in Infectious Diseases to promote translational synergy between Laboratory Science, Clinical Medicine and Public Health. The Journal invites Original Articles, Clinical Investigations, Epidemiological Analysis, Data Protocols, Case Reports, Clinical Photographs, review articles and special commentaries. Students, Residents, Academicians, Public Health experts and scientists are all encouraged to be a part of this initiative by contributing, reviewing and promoting scientific works and science.
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