Identifying major life events associated with insomnia disorder: Stressors that disrupt safety, stability, and identity

IF 4.8 2区 医学 Q2 CLINICAL NEUROLOGY
Sleep Health Pub Date : 2026-06-01 Epub Date: 2026-04-08 DOI:10.1016/j.sleh.2026.02.010
Matthew B. Jennings PhD , David A. Kalmbach PhD , Philip Cheng PhD , Anthony N. Reffi PhD , Thomas Roth PhD , Christopher L. Drake PhD
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引用次数: 0

Abstract

Objectives

Major life stress is a well-established precipitating factor for insomnia disorder. However, not all stressors are equally harmful, and determining which events pose the greatest risk to sleep is not well-understood. Identifying high-impact stressors on insomnia will deepen our understanding of how this disorder develops, particularly among those most vulnerable to insomnia. The present study explored a wide range of major life events to identify which stressors were associated with incident insomnia disorder.

Methods

This study assessed a large cohort (N = 2887) of U.S. adults across three timepoints: baseline, 1-year follow-up, and 2-year follow-up. Mixed-effects logistic regression was used to explore the association of major life events (Social Readjustment Rating Scale) with DSM-IV-TR insomnia disorder classification, controlling for sociodemographic factors. Differences by sleep reactivity (Ford Insomnia Response to Stress Test) were examined post hoc.

Results

Fifteen major life stressors significantly predicted incident insomnia disorder. Key triggers included interpersonal stressors (e.g., infidelity, exposure to violence), work stressors (e.g., job loss, losing health benefits), home stressors (e.g., financial difficulties), and major injury/illness to oneself or close family member. The highest rates of insomnia onset were reported by highly reactive sleepers faced with major life stress (≥19%), whereas the lowest rates of insomnia were reported by low-reactive sleepers unexposed to major stress (≈5%).

Conclusions

Major stressors were most harmful when they threatened an individual’s stability, safety, and core identity. Highly reactive sleepers may experience high levels of sustained hyperarousal when exposed to these high-impact stressors, thereby increasing the risk of insomnia disorder.
识别与失眠症相关的主要生活事件:破坏安全、稳定和身份的压力源。
目的:重大生活压力是失眠障碍的一个公认的诱发因素。然而,并不是所有的压力源都同样有害,而且确定哪些事件对睡眠构成最大的风险还不是很清楚。确定高影响压力因素对失眠的影响将加深我们对这种疾病如何发展的理解,特别是在那些最容易失眠的人群中。本研究探讨了一系列重大生活事件,以确定哪些压力源与偶发性失眠有关。方法:本研究评估了一个大队列(N = 2887)的美国成年人在三个时间点:基线,1年随访和2年随访。在控制社会人口学因素的情况下,采用混合效应logistic回归探讨重大生活事件(社会再适应评定量表)与DSM-IV-TR失眠症分类的关系。睡眠反应的差异(福特失眠对压力测试的反应)被事后检查。结果:15种主要生活压力源对失眠事件有显著预测作用。主要触发因素包括人际压力因素(如不忠、遭受暴力)、工作压力因素(如失业、失去健康福利)、家庭压力因素(如经济困难)以及自己或亲密家庭成员的重大伤害/疾病。面对重大生活压力的高反应性睡眠者失眠发生率最高(≥19%),而未暴露于重大压力的低反应性睡眠者失眠发生率最低(≈5%)。结论:当主要压力源威胁到个体的稳定性、安全性和核心身份时,其危害最大。高反应性睡眠者在暴露于这些高影响压力源时可能会经历高水平的持续过度觉醒,从而增加失眠障碍的风险。
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来源期刊
Sleep Health
Sleep Health CLINICAL NEUROLOGY-
CiteScore
6.30
自引率
9.80%
发文量
114
审稿时长
54 days
期刊介绍: Sleep Health Journal of the National Sleep Foundation is a multidisciplinary journal that explores sleep''s role in population health and elucidates the social science perspective on sleep and health. Aligned with the National Sleep Foundation''s global authoritative, evidence-based voice for sleep health, the journal serves as the foremost publication for manuscripts that advance the sleep health of all members of society.The scope of the journal extends across diverse sleep-related fields, including anthropology, education, health services research, human development, international health, law, mental health, nursing, nutrition, psychology, public health, public policy, fatigue management, transportation, social work, and sociology. The journal welcomes original research articles, review articles, brief reports, special articles, letters to the editor, editorials, and commentaries.
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