Determinants of Improved Dyspnea and Exercise Tolerance With Nasal High-Flow O₂ Therapy in Fibrotic Interstitial Lung Disease: A Pilot Physiological Study.

IF 7.2 2区医学 Q1 RESPIRATORY SYSTEM

Respirology Pub Date : 2026-07-01 Epub Date: 2026-04-09 DOI:10.1002/resp.70251

Sarah Thivent, Marylise Ginoux, Samuel Verges, Frédéric Hérengt, Mathieu Marillier

引用次数: 0

Abstract

We tested the respective effect of high-flow and supplemental O₂ from nasal high-flow O₂ therapy (NHFO₂) on dyspnea and exercise tolerance in fibrotic interstitial lung disease. Supplemental O₂ and NHFO₂ (but not high-flow) provided improvements in these outcomes at "iso-O₂ saturation" due to reduced ventilatory requirements. Physiological benefits derived from O₂ supplementation are thus likely primary drivers of dyspnea relief and improved exercise tolerance on NHFO₂ (vs air) in these patients.

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在纤维化间质性肺疾病中鼻高流量氧治疗改善呼吸困难和运动耐量的决定因素：一项初步生理学研究。

我们测试了高流量氧气和鼻高流量氧气治疗（NHFO2）对纤维化间质性肺病患者呼吸困难和运动耐量的影响。补充O2和NHFO2（但不是高流量）由于降低了通气需求，在“等氧饱和度”下改善了这些结果。因此，补充氧气带来的生理益处可能是这些患者呼吸困难缓解和改善NHFO2（相对于空气）运动耐受性的主要驱动因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Respirology 医学-呼吸系统

CiteScore

10.60

自引率

5.80%

发文量

225

审稿时长

1 months

期刊介绍： Respirology is a journal of international standing, publishing peer-reviewed articles of scientific excellence in clinical and clinically-relevant experimental respiratory biology and disease. Fields of research include immunology, intensive and critical care, epidemiology, cell and molecular biology, pathology, pharmacology, physiology, paediatric respiratory medicine, clinical trials, interventional pulmonology and thoracic surgery. The Journal aims to encourage the international exchange of results and publishes papers in the following categories: Original Articles, Editorials, Reviews, and Correspondences. Respirology is the preferred journal of the Thoracic Society of Australia and New Zealand, has been adopted as the preferred English journal of the Japanese Respiratory Society and the Taiwan Society of Pulmonary and Critical Care Medicine and is an official journal of the World Association for Bronchology and Interventional Pulmonology.

Determinants of Improved Dyspnea and Exercise Tolerance With Nasal High-Flow O2 Therapy in Fibrotic Interstitial Lung Disease: A Pilot Physiological Study.

Abstract

Determinants of Improved Dyspnea and Exercise Tolerance With Nasal High-Flow O₂ Therapy in Fibrotic Interstitial Lung Disease: A Pilot Physiological Study.