Chromodomain Helicase DNA-Binding Proteins and Spermatogenesis: Current Advances.

IF 3.4 2区医学 Q1 ANDROLOGY

Andrology Pub Date : 2026-04-10 DOI:10.1111/andr.70232

Mingrui Zhang, Di Liu, Guoqiang Liu, Minggang Zhu, Feng Pan

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引用次数: 0

Abstract

Background: Male infertility is a prevalent clinical condition, with approximately one-third of cases classified as idiopathic, frequently stemming from impaired spermatogenesis because of dysregulated gene expression. Chromodomain helicase DNA-binding (CHD) proteins are central chromatin remodelers that orchestrate this epigenetic regulation. For instance, smoking-induced hypermethylation of the CHD5 gene promoter is associated with impaired semen parameters.

Objective: This review aims to summarize the roles and mechanisms of CHD proteins in spermatogenesis, explore their relationship with male infertility, and discuss their potential as diagnostic and therapeutic targets.

Methods: A comprehensive literature review was conducted to synthesize current findings on the expression and function of CHD proteins across different stages of spermatogenesis.

Results: Research has shown that CHD proteins are expressed in the testis and play crucial roles in multiple stages of spermatogenesis, from spermatogonial stem cell (SSC) maintenance to spermatid maturation, making them promising targets for understanding and treating male infertility.

Conclusion: CHD proteins represent important epigenetic regulators in spermatogenesis and may serve as valuable biomarkers or therapeutic targets for male infertility.

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染色体结构域解旋酶dna结合蛋白与精子发生：最新进展。

背景：男性不育症是一种普遍的临床疾病，大约三分之一的病例被归类为特发性，通常源于基因表达失调导致的精子发生受损。染色质解旋酶dna结合（CHD）蛋白是协调这种表观遗传调控的中心染色质重塑者。例如，吸烟引起的CHD5基因启动子的高甲基化与精液参数受损有关。目的：综述冠心病蛋白在精子发生中的作用和机制，探讨其与男性不育的关系，并探讨其作为诊断和治疗靶点的潜力。方法：通过文献综述，综合目前关于冠心病蛋白在精子发生不同阶段的表达和功能的研究成果。结果：研究表明，CHD蛋白在睾丸中表达，并在精子发生的多个阶段发挥重要作用，从精原干细胞（SSC）维持到精子成熟，使其成为了解和治疗男性不育症的有希望的靶点。结论：冠心病蛋白是精子发生过程中重要的表观遗传调控因子，可能是男性不育的有价值的生物标志物或治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Andrology ANDROLOGY-

CiteScore

9.10

自引率

6.70%

发文量

200

期刊介绍： Andrology is the study of the male reproductive system and other male gender related health issues. Andrology deals with basic and clinical aspects of the male reproductive system (gonads, endocrine and accessory organs) in all species, including the diagnosis and treatment of medical problems associated with sexual development, infertility, sexual dysfunction, sex hormone action and other urological problems. In medicine, Andrology as a specialty is a recent development, as it had previously been considered a subspecialty of urology or endocrinology