{"title":"West Nile Morbidity and Mortality in a Mid-Atlantic Health Care System, 2013-2024.","authors":"Seth D Judson, Paul Auwaerter, David Dowdy","doi":"10.4269/ajtmh.26-0008","DOIUrl":null,"url":null,"abstract":"<p><p>West Nile virus (WNV) is transmitted by mosquitoes to humans in many regions and can cause neuroinvasive disease and death. To better understand the local burden of disease caused by WNV and risk factors for disease severity, we analyzed cases from across the Johns Hopkins Health System Corporation. We identified 86 patients who met confirmed/probable case definitions for WNV infection from 2013 to 2024. Seventy-one patients (83%) had West Nile neuroinvasive disease (WNND), and nine (10%) died. Encephalitis (n = 47) was the most common complication and was associated with increased age, alcohol use disorder, immunocompromised status, and a higher Charlson Comorbidity Index. Of the 21 patients in the cohort who were immunocompromised, 20 (95%) developed WNND, and 4 (19%) died. The overall median hospital length of stay was 8 days (interquartile range 5-15). People diagnosed with WNV in this health care system experienced significant morbidity and mortality from WNND, notably when immunocompromised.</p>","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.6000,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Tropical Medicine and Hygiene","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4269/ajtmh.26-0008","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
引用次数: 0
Abstract
West Nile virus (WNV) is transmitted by mosquitoes to humans in many regions and can cause neuroinvasive disease and death. To better understand the local burden of disease caused by WNV and risk factors for disease severity, we analyzed cases from across the Johns Hopkins Health System Corporation. We identified 86 patients who met confirmed/probable case definitions for WNV infection from 2013 to 2024. Seventy-one patients (83%) had West Nile neuroinvasive disease (WNND), and nine (10%) died. Encephalitis (n = 47) was the most common complication and was associated with increased age, alcohol use disorder, immunocompromised status, and a higher Charlson Comorbidity Index. Of the 21 patients in the cohort who were immunocompromised, 20 (95%) developed WNND, and 4 (19%) died. The overall median hospital length of stay was 8 days (interquartile range 5-15). People diagnosed with WNV in this health care system experienced significant morbidity and mortality from WNND, notably when immunocompromised.
期刊介绍：
The American Journal of Tropical Medicine and Hygiene, established in 1921, is published monthly by the American Society of Tropical Medicine and Hygiene. It is among the top-ranked tropical medicine journals in the world publishing original scientific articles and the latest science covering new research with an emphasis on population, clinical and laboratory science and the application of technology in the fields of tropical medicine, parasitology, immunology, infectious diseases, epidemiology, basic and molecular biology, virology and international medicine.
The Journal publishes unsolicited peer-reviewed manuscripts, review articles, short reports, images in Clinical Tropical Medicine, case studies, reports on the efficacy of new drugs and methods of treatment, prevention and control methodologies,new testing methods and equipment, book reports and Letters to the Editor. Topics range from applied epidemiology in such relevant areas as AIDS to the molecular biology of vaccine development.
The Journal is of interest to epidemiologists, parasitologists, virologists, clinicians, entomologists and public health officials who are concerned with health issues of the tropics, developing nations and emerging infectious diseases. Major granting institutions including philanthropic and governmental institutions active in the public health field, and medical and scientific libraries throughout the world purchase the Journal.
Two or more supplements to the Journal on topics of special interest are published annually. These supplements represent comprehensive and multidisciplinary discussions of issues of concern to tropical disease specialists and health issues of developing countries
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